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Study: Artificial sweeteners toxic to digestive gut bacteria

cnbc.com

51–60 of 137 posts

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#51

Earlier quoted context omitted.

>an 8 oz. cup of coffee with 16 packets of Splenda. I have literally seen people do such things at Dunkin Donuts. "Yeah can I get a medium coffee with extra cream and 20 sugars." You WUT M8?

At a certain point you have to admit to yourself that you just don't like coffee.

With that much sugar I'm not sure if it's the flavour or texture you don't like.

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#52

The article doesn't say which sweeteners did they study and this is a very bad style. Fortunately it links to an article on EurekAlert which in its turn links to the actual scientific paper (doi.org/10.3390/molecules23102454). It says aspartame, sucralose, saccharine, neotame, advantame and acesulfame potassium-k (ace-k) (BTW at least saccharine and ace-k are already known to be carcinogenic AFAIK) were tested agains…

>BTW at least saccharine ad ace-k are already known to be carcinogenic AFAIK

Not according to the National Cancer Institute [1]. The amount of misinformation in nutrition is frustrating at times.

[1] https://www.cancer.gov/about-cancer/causes-prevention/risk/d...

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#53
The underlying research article (https://www.mdpi.com/1420-3049/23/10/2454) is set up as a "no-fail" experiment since it infers toxicity with the slightest change (inhibition or induction) in a very sensitive reporter (luciferase). They are NOT measuring change in growth rate of the bacterial cells, the traditional measure of toxicity (aka IC, or inhibitory concentration). The study has positive and negative controls, but this assay is poorly controlled relative to how it is being interpreted (impact of artificial sweeteners on human gut microbiome).

The only way to accurately calibrate this novel assay for relevance to human health is to expose the bacteria to a wide range of natural foods (e.g., avocado, spinach, berries, honey, etc) and show that it does not return a positive result. If nearly everything is toxic, the assay is not useful. However, if most natural foods have no toxicity signal, then the assay has genuine value.

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#55

Seems like everything has artificial sweeteners nowadays. It's a trend that I noticed only in the last couple of years. And not just fizzy drinks like Sprite or Pepsi - which have sugar and sweetener! - but breakfast cereals, yoghurts, ketchup-like sauces... all have "no added sugar" on the package, you dig a bit deeper and they are full of sweeteners. Chewing gum and other "healthy sweet" products like that have use…

> or it'll give you the shits

I believe that's a common side effect of sugar alcohols like xylitol.

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#56

There are only 12 milligrams of sucralose in a packet of Splenda. So the toxic levels found in mice had the same concentration as an 8 oz. cup of coffee with 16 packets of Splenda.

>an 8 oz. cup of coffee with 16 packets of Splenda. I have literally seen people do such things at Dunkin Donuts. "Yeah can I get a medium coffee with extra cream and 20 sugars." You WUT M8?

I feel like we're ignoring scale here. 16 packets of Splenda in a mouse's stomach.

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#57
Top comment at r/science:

Ordinary table salt and most other essential non-organic mineral naturally found in healthy foods, are toxic in increasing doses to bacteria. As a biochemist I'd be willing to bet that those necessary minerals in the human diet would stress the hell out of these bacteria in increasing doses also. The bacteria in this paper do NOT show growth inhibition with these artificial sweeteners in the doses used.

It's a pretty huge jump in scientific presumption - from a change in fluorescence in a contrived sub-inhibitory bacterial "stress" assay, to the authors statement of "we may speculate that the response observed in our study may be relevant to gut microbiome and thus may influence human health". (statements in italics not tested by authors)

So doubt their basic premise has any validity.

https://www.reddit.com/r/science/comments/9ki9nw/scientists_...

Not only that, they were only using a fluorescing E. coli as a proxy for the incredibly diverse gut microbiota. For it to have any real bearing on human health, they'd need to do at least an animal model study and show a difference in 16s rRNA quantitation and/or sequencing for relative abundances of different species. But I sympathize with the need to make your study sound significant and worth doing....

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#59

Seems like everything has artificial sweeteners nowadays. It's a trend that I noticed only in the last couple of years. And not just fizzy drinks like Sprite or Pepsi - which have sugar and sweetener! - but breakfast cereals, yoghurts, ketchup-like sauces... all have "no added sugar" on the package, you dig a bit deeper and they are full of sweeteners. Chewing gum and other "healthy sweet" products like that have use…

> Clearly bad for your gut or you wouldn't be getting these side effects.

That's not how that works. Ifyou eat too much fruit the sugar in that can cause a laxative effect,and the mecahnism is the same as with suga alcohols. The undigested sugar causes osmosis, which floods the gut with water, which causes diarrhea.

Re: Study: Artificial sweeteners toxic to digestive gut bacteria

#60
post #43

Earlier quoted context omitted.

Refined oils, fat, and animal protien cause arterial hardening immediately, lasting for several hours. Keep ingesting and you end up with heart disease....arteries filled with plaque restricting blood flow, raspiration, mental function. Ingesting refined sugar and flour causes an insulin spike (make fat out of carbs!) that lasts for hours causing a crash and repeated cravings for...more carbs. This leads to diabetes.…

Citation for proof that arterial hardening happens immediately, and that animal protein specifically causes this (vs plant protein)? I've not seen this specific claim before.

I've seen the claim about animal protein many times before, never the sources.
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