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Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

ncbi.nlm.nih.gov

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Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#11

Post by interfixus »

Nasrudith wrote: post #8
mrhappyunhappy wrote: post #2

If the naked mole rat does not age in terms of negative consequences of age, what makes them die at 30?

What makes them die younger is the real question. Their curve is pretty flat as a trend line (although with plenty of peaks and valleys) and seems to start at 600 day old mouse mortality rates. Although they are also infamously inbred. I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them or if it would do about as much good as breeding for resistance to gunshots - outside ci…

Of course you can breed for resistance to gunshots. Size, hardened skin, extreme speed of ducking reflex, regenerative capacity, spiderlike weaving ability etc. etc.

Long term project, but in principle.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#12

Post by rincebrain »

solveit wrote: post #10
Nasrudith wrote: post #8

Earlier quoted context omitted.

What makes them die younger is the real question. Their curve is pretty flat as a trend line (although with plenty of peaks and valleys) and seems to start at 600 day old mouse mortality rates. Although they are also infamously inbred. I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them or if it would do about as much good as breeding for resistance to gunshots - outside ci…

It works on fruit flies, see Rose, M. Laboratory Evolution of Postponed Senescence in Drosophila melanogaster. Evolution (1984), where the lifespan was doubled. So this certainly works in principle. For longer lived species I expect it will still work, but it would take hundreds to thousands of years to breed for even a few dozen generations.

I would be concerned with secondary effects of aging on viability of gametes and chances of exotic conditions - doing this over any large span of generations would probably (temporarily?) yield a much higher mortality rate until we figured out the best ratio of increased parent lifespan to increased child mortality.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#14

Post by tejtm »

mrhappyunhappy wrote: post #2

If the naked mole rat does not age in terms of negative consequences of age, what makes them die at 30?

The same things that make them die at three years old. The point is the rate of those things which kill, does not increase as much with age as it does with the rest of us mammals.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#15

Post by adrianN »

rincebrain wrote: post #12
solveit wrote: post #10

Earlier quoted context omitted.

It works on fruit flies, see Rose, M. Laboratory Evolution of Postponed Senescence in Drosophila melanogaster. Evolution (1984), where the lifespan was doubled. So this certainly works in principle. For longer lived species I expect it will still work, but it would take hundreds to thousands of years to breed for even a few dozen generations.

I would be concerned with secondary effects of aging on viability of gametes and chances of exotic conditions - doing this over any large span of generations would probably (temporarily?) yield a much higher mortality rate until we figured out the best ratio of increased parent lifespan to increased child mortality.

With humans you probably wouldn't want to wait with the breeding until the parents are old, but select breeding pairs based on the longevity of their (great-)grandparents. At least until you figure out useful biomarkers that reliably predict longevity already at the age of twenty or so.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#16

Post by lawlessone »

sungam wrote: post #13

Could it not be that the lifespan is just significantly longer than the observation period? If we looked at human mortality in a sample of a few thousand individuals over the first 30 years of life it would also appear rather flat.

>If we looked at human mortality in a sample of a few thousand individuals over the first 30 years of life it would also appear rather flat.

it's not

https://en.wikipedia.org/wiki/Gompertz%E2%80%93Makeham_law_o...

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#17

Post by halfdan »

Nasrudith wrote: post #8
mrhappyunhappy wrote: post #2

If the naked mole rat does not age in terms of negative consequences of age, what makes them die at 30?

What makes them die younger is the real question. Their curve is pretty flat as a trend line (although with plenty of peaks and valleys) and seems to start at 600 day old mouse mortality rates. Although they are also infamously inbred. I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them or if it would do about as much good as breeding for resistance to gunshots - outside ci…

> I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them

You wouldn't want to breed the 'elders' but the offspring of 'elderly' naked mole rats.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#19

Post by Retric »

lawlessone wrote: post #16
sungam wrote: post #13

Could it not be that the lifespan is just significantly longer than the observation period? If we looked at human mortality in a sample of a few thousand individuals over the first 30 years of life it would also appear rather flat.

>If we looked at human mortality in a sample of a few thousand individuals over the first 30 years of life it would also appear rather flat. it's not https://en.wikipedia.org/wiki/Gompertz%E2%80%93Makeham_law_o...

He is actually mentioning a real effect. Note the flat part around 20-30 years old:

https://en.wikipedia.org/wiki/Gompertz%E2%80%93Makeham_law_o...

If that's all the data you had it would look like an S curve with an odd starting anomaly at <1 year old.

Re: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age [pdf]

#20

Post by mdonahoe »

what is "censorship" as defined in that study?

Example in context: ". Right-censorship was applied in three cases: if the animal was (1) transferred to another collection, with the date of transfer considered as the censorship event; (2) euthanized for research purposes when still healthy, with the date of sacrifice as the censorship event; or (3) still alive when the process of compiling records was completed, with the date of completion as the censorship event (see Materials and methods)."

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