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Infectious Theory of Alzheimer's Disease Draws Fresh Interest

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Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#51
post #28

Earlier quoted context omitted.

This research could make it only more cruel. Proof that it is caused by a germ, that is may be catching, would suggest that sufferers should be isolated from healthy people to prevent spread of the infection. Id be happy if it were caused by bacteria or a virus. Those we can deal with. But what if it is a prion like bse? Could it linger in houses? Are nursing homes now a biohazard? Dark days. The link between viruses…

It's almost certainly not infectious in that kind of way or you'd notice the nurses in the old folks homes getting it.

From an article cited in the OP:

"Neurosurgeons were more likely to die of Alzheimer disease, other nonneoplastic nonvascular nervous system disease, leukemia, and aircraft accidents, when compared with the general population."

That looks like persons exposed to the brains of patients may be catching something.

What if it was a germ? How would one go about finding it? Where would one find the non-infected population with which to compare? It may be a combination of a germ and genetics and that germ may be pervasive in our environment, but that doesn't mean the germ cannot be isolated or even eradicated. So it is worth investigation. We may need to find people (monks?) who have lived without exposure to people with dementia, an interesting anthropological problem imho.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#52
post #43

Earlier quoted context omitted.

Worst case: they are getting it, but not finding out until they themselves reach old age.

I think even that would be noticed by now. If almost every person that worked in a nursing home 30 years ago are getting Alzheimer's.

But why assume that people who work in nursing homes will be more exposed? Work is only part of the day. A great many more people live with elderly/dementia patients in their homes. We are all in contact with such people daily. If there were a germ that we could 'catch', I wouldn't assume that people in nursing homes were a special population. We may all have it.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#53
post #37

Earlier quoted context omitted.

Nursing homes are among the cruelest and most in humane institutions, worse than prison in many ways. Anything that avoids nursing home days is worth it’s weight in gold.

I have worked in many as a care aid providin direct care to residents. I worked for 7 years in one facility that worked with advanced Alzheimer's and dementia like condition clients. I would not describe the nursing home as cruel or in-human, though to a person with sound mind it certainly would. The people who resided there simply could not live alone. They would soon be seriously hurt or die. So yes when they enter…

There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself).

Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "awards" for the excellence of their care. Just the tip of the iceberg: staff physicians who never, ever appear on site, yet who collects a paycheck by prescribing tranquilizing drugs for any resident at the facility's request, all sight unseen. The facility routinely dubs its residents as "troublesome" or "aggressive" to dope them up and 1) mean they have to provide no active care, because turnips in wheelchairs/beds don't do anything and 2) ensure a relatively quick decline in all residents, because total immobility is a great slow-acting poison, especially on the vulnerable elderly. Thus quick turnover and higher profits are ensured, all while labor costs are kept low. Eventually good facilities were found, the best of which was a wonderful VA program in a home with a live-in nurse, specializing in care for those with dementia. But not before the horror shows had taken their toll.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#54
post #2

Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.

If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression better than any other drug. Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Methylene blue is a potent antimicro…

thanks for your post. That would be funny if the cure is to drink the "Methylene Blue Kool Aid"

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#55
post #2

Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.

This research could make it only more cruel. Proof that it is caused by a germ, that is may be catching, would suggest that sufferers should be isolated from healthy people to prevent spread of the infection. Id be happy if it were caused by bacteria or a virus. Those we can deal with. But what if it is a prion like bse? Could it linger in houses? Are nursing homes now a biohazard? Dark days. The link between viruses…

Infectious etiology is not the same as being contagious. We know HPV causes increased cancer risk, but we don't treat folks with those cancers as contagious. They're not. But their malignancies do have an infectious cause - infection earlier in life. That's the relationship being proposed here with Alzheimer's. Understanding the nature of a disease is a prerequisite for developing better treatments. We should not the imaginary social fears of the uninformed get in the way of that exploration.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#56

Earlier quoted context omitted.

Thanks. What’s your take on this article: https://jeffreydachmd.com/wp-content/uploads/2015/06/Efficac... Maybe you should get this vaccine instead of valtrex? Or both?

Wait, is that a cure for herpes?

No, sadly. Just a vaccine for varicella.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#57
post #28

Earlier quoted context omitted.

This research could make it only more cruel. Proof that it is caused by a germ, that is may be catching, would suggest that sufferers should be isolated from healthy people to prevent spread of the infection. Id be happy if it were caused by bacteria or a virus. Those we can deal with. But what if it is a prion like bse? Could it linger in houses? Are nursing homes now a biohazard? Dark days. The link between viruses…

It's almost certainly not infectious in that kind of way or you'd notice the nurses in the old folks homes getting it.

There are some viruses that basically everyone gets that then lay latent for the rest of your life. So yes if one of those were a cause then epidemiological data wouldn't be much help.

Not a crazy thoery, one of the complications of measles is a fatal encephalitis that occurs 5-20 years later.

Be nice if they figured it out, Alzheimer's Disease means years of suck quality of life for everyone.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#58
post #2

Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.

If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression better than any other drug. Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Methylene blue is a potent antimicro…

Methylene blue is also an monoamine oxidase inhibitor. I add it to my dog’s food to boost her metabolism. She blew her knee out a year ago (common injury for large 10yo dogs) but has mostly recovered without the surgery the vet said she’d probably need. (I use a variety of interventions with her.)

Methylene blue should not be combined with the later anti-depressants that focus more on serotonin (SSRIs, etc.), as this can cause serotonin toxicity: https://www.apsf.org/article/methylene-blue-and-the-risk-of-...

> Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works.

Patent medicines [1] are still as popular as they ever were. Science made some inroads in the early 20th century, before the hucksters regrouped, with new prescription-only FDA approved nostrums.

[1] https://en.m.wikipedia.org/wiki/Patent_medicine

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#59
post #49

Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143

[deleted]

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#60
post #56

Earlier quoted context omitted.

Wait, is that a cure for herpes?

No, sadly. Just a vaccine for varicella.

So how do you explain the results:

"Results: From 2005 through 2011, for the 24 anti-VZV vaccinated patients, the average number of herpes relapses decreased to 0, correlated with an increased anti-VZV antibody level and clinical recovery of all patients, whereas no improvement was observed for the 26 nonvaccinated herpes patients."

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