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Infectious Theory of Alzheimer's Disease Draws Fresh Interest

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Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#41
post #32
post #2

Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.

And that is but one reason why our system of health care is immoral. Not amoral. People who are sick, their families watching, are not able to make rational economic decisions. These things should be decided when we are rational, as a society, and my preference is the "veil of ignorance" approach provided by John Rawls. If you don't know what disease you get, what your native tongue is, whether you're rich or poor, w…

I haven't thought or Rawls in quite a while.

The idea of a "veil of ignorance" as a mode of capturing the implications of some political position is a useful, wide-ranging, and easily digestible ethical concept; I'm going to add it back into my intellectual tool bag for when I am trying to discuss ethics with folks.

Thanks for the reminder.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#42
post #29

Earlier quoted context omitted.

> The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please. Experts please correct me if I'm wrong, but even if this theory were to be proven true, how could it help anyone once the damage is done?

I'm wondering, after the recent finding that herpes anti virals can reduce the chance of getting alzhemiers by up to 10x whether its worth trying them on my dad who's got some kind of dementia. Not sure if it's got a chance of working. The drugs are fairly cheap widely available and low side effects - the same stuff you take for cold sores. I guess the idea would be if you could control viral stuff the bodies normal…

It sounds like you take some concern into your dads health and that you care. I would encourage you to be open and ask questions and find the information you need to help how you can. Maybe that is talking to your mom or if he is alone perhaps start a conversation with his doctor. If this is just something you have noticed but hasn't gone through the doctor I highly encourage you to do so. There are several causes to dementia. One being Alzheimer's as most know example but there are other types of dementia like vascular dementia where medications absolutely can help to some extent. Anyways don't be afraid to ask the questions. Wish you and your family best regards with all this.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#43
post #28

Earlier quoted context omitted.

It's almost certainly not infectious in that kind of way or you'd notice the nurses in the old folks homes getting it.

Worst case: they are getting it, but not finding out until they themselves reach old age.

I think even that would be noticed by now. If almost every person that worked in a nursing home 30 years ago are getting Alzheimer's.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#44
post #15

Earlier quoted context omitted.

The amusing thing about your "cynicism" here is that $200,000 would be a substantial savings compared to what happens now, never mind the huge value an effective treatment would provide. In the US, the government (and thus society at large) bears much of the cost: http://act.alz.org/site/DocServer/2012_Costs_Fact_Sheet_vers...

4-5 years of a nursing home vs cured alzheimer's isn't even a hard decision

Looking at ~350k-400k for my dad if he lives another 5 years. Given his spending before Alzheimer's 200k would be an easy choice for us even even from a purely cold financial perspective.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#45
post #37

Earlier quoted context omitted.

Nursing homes are among the cruelest and most in humane institutions, worse than prison in many ways. Anything that avoids nursing home days is worth it’s weight in gold.

I have worked in many as a care aid providin direct care to residents. I worked for 7 years in one facility that worked with advanced Alzheimer's and dementia like condition clients. I would not describe the nursing home as cruel or in-human, though to a person with sound mind it certainly would. The people who resided there simply could not live alone. They would soon be seriously hurt or die. So yes when they enter…

My grandpa spent the last several years of his life with Alzheimers in a nursing home. Furthermore, I spent several years as a telephone technician, and I worked plenty in nursing homes. My overall impression (at least of the ones in my county) is that they are poorly managed and the employees are overworked, and presumably are very underfunded. My grandpa received excellent care, but that was because my grandma went in almost every day to check in on him. There were several occasions when she raised hell because he wasn't being taken care of properly.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#46
post #2

Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.

If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression better than any other drug. Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works.

Methylene blue is a potent antimicrobial that easily penetrates the blood brain barrier, so it working so well would be consistent with Alzheimers being an infectious disease.

[1]https://content.iospress.com/download/journal-of-alzheimers-...

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#47
post #4

Earlier quoted context omitted.

How would you know if you had HSV? My impression was that a lot of infections are so mild that those with them don't realize they had it.

> How would you know if you had HSV? My impression was that a lot of infections are so mild that those with them don't realize they had it. That's true. There's a blood test you can do, though.

My understanding is that the (old?) test is sensitive to both HSV1 (oral cold sores) as well as HSV2 (genital) because their protein coats are similar... so if you have cold sores you'll test positive even if you don't have HSV2. Of course their effect on the brain could be similar... although more than 50% of people have HSV1.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#48
post #10
post #8

Earlier quoted context omitted.

You seem really knowledgeable about this stuff. I’d be curious what diet you’d recommend for a two copy apoe4?

Not an expert, but probably should avoid arginine and take more lysine. https://www.ncbi.nlm.nih.gov/pubmed/19288025 https://www.ncbi.nlm.nih.gov/pubmed/3115841 Anyway, I think it's about time we get some big-data results on diet and illness. Question is: where is the data and how do we get access?

Doesn’t that abstract say that arginine inhibits hsv?

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#49
Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain.

[1] https://www.ncbi.nlm.nih.gov/pubmed/12480752

[2] https://www.ncbi.nlm.nih.gov/pubmed/24489130

[3] https://www.ncbi.nlm.nih.gov/pubmed/23239205

[4] http://www.ncbi.nlm.nih.gov/pubmed/20695015

[5] http://www.ncbi.nlm.nih.gov/pubmed/15699381

[6] http://www.ncbi.nlm.nih.gov/pubmed/23204143

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#50
post #9

Earlier quoted context omitted.

Not a doctor; can't give you medical advice. Just giving deductions I'm making based on current research which could all play out to be very, very wrong. Valacyclovir is brand-named Valtrex. Basically, if you're ever diagnosed with herpes of any variant, you should ask your doctor about what to expect if you go on Valacyclovir to ward off recurring outbreaks. If those side effects don't sound disagreeable to you v. t…

Thanks. What’s your take on this article: https://jeffreydachmd.com/wp-content/uploads/2015/06/Efficac... Maybe you should get this vaccine instead of valtrex? Or both?

Wait, is that a cure for herpes?
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