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Eating in 10-hour window can override disease-causing genetic defects

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Re: Eating in 10-hour window can override disease-causing genetic defects

#61

Post by DannyBee »

ainar-g wrote: post #41
projectramo wrote: post #8

Another major victory in mankind’s long quest to render mice immortal.

For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight: >After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a do…

I believe it concludes that while 500x lower, 0.1mg would bind 85-98% of all possible CD28 receptors -meaning that "small" dose would have shown the maximum effect of the drug.

Re: Eating in 10-hour window can override disease-causing genetic defects

#62

Post by abledon »

Franciscouzo wrote: post #29
abledon wrote: post #9

Earlier quoted context omitted.

Middle of the day for largest meal. Try to eat less before bed so liver can detox instead of digest food while u sleep. Also if your a man try working on peacock pose each morning 30 mins before eating (up to 5 mins) to boost digestion , if woman be careful when menstruating

Everything you said sounds like bullshit, do you have any source to back it up?

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072577/

Through an evolution lense we evolved to not be eating huge meals in the middle of the night. When the liver doesn’t have to work on digestion it can better focus on the myriad of other tasks it’s responsible for.

As for mayurasana, I doubt any pharma company is going to drop 500 Gs to perform a double blind random controlled study with >1000 participants , but just try it for a month: http://www.hathayogamysore.com/asanas/mayurasana-the-peacock “”” Benefits of The Peacock (Mayurasana) 1. Because of the pressure on the abdomen,the blood is directed towards the digestive organs.as the intra-abdominal pressure is increased,the abdominal viscera is toned 2. Liver,pancreas,stomach and spleen are invigorated.The nerves and muscles connected with the kidneys and intestines are revitalised. 3. Sluggishness of the liver or hepatic torpidity disappears. “””

It’s dangerous for women because the intense pressure and slight inversion can mess up their menstrual process during the height of it (3day span usually). Sadly no pharma studies are available on this (what company would drop money on studying that !)

Re: Eating in 10-hour window can override disease-causing genetic defects

#63

Post by cageface »

browsercoin wrote: post #27

Is it possible that with economic affluence of the West, overconsumption is harmful? It used to be that there would be days where our ancestors would not be able to bring home any meat so fasting probably was built in as part of our metabolism process. It was only in the past 100 years that we've seen mass produced sugary food and drinks. Like the diet difference is painfully obvious when you go to Japan's 7-11. Heal…

I live in Vietnam but we have a lot of Koreans in the area I live in and what they eat doesn't seem very healthy. Huge amounts of cheese and grilled meats and very heavy drinking. Is that typical for Koreans in Korea too?

Re: Eating in 10-hour window can override disease-causing genetic defects

#64

Post by nickjj »

coldtea wrote: post #58
nickjj wrote: post #47

I'm kind of surprised this isn't the default for most people. For example let's say you eat dinner at 6-7pm and then goto bed at 11pm. After that you wake up around 7am and then maybe eat breakfast an hour or 2 later. At this point you've gone from about 7pm to 8am or 9am without eating (~13-14 hours) but it fits pretty well into a schedule. Wouldn't you have to really go out of your way to deviate from that? Of cour…

> Wouldn't you have to really go out of your way to deviate from that? Depends on the country and culture. In these here parts we still go to work at 8am or 9am, but we dine at 10pm or later (going to a restaurant at 11pm is very common, and similarly for eating at home).

What time do you get home from work?

That sounds like an unreasonably long day if you have to be in work by 8am but you're still at a restaurant at 11pm.

I'm from the US btw. I happen to do freelance work but most people I know work from about 9am to 5pm where they leave the house around 8:30am and are home by 5:30pm or 6pm at the latest.

Eating breakfast at 8am and dinner at 7pm is normal for them, or sometimes they skip breakfast at home and eat something small at work.

Re: Eating in 10-hour window can override disease-causing genetic defects

#65

Post by will_brown »

coldtea wrote: post #57
will_brown wrote: post #12

Earlier quoted context omitted.

Definitely if you trigger insulin response it is safe to say you break a fast, but any caloric intake breaks the fast, even without insulin response. I’m not sure that video supports your conclusion that coffee/tea breaks the fast, seems to me it’s more of a maybe . I personally appreciated the acknowledgement of the microbiome. The idea that simply...we don’t know and don’t understand the interactions of the microbi…

> Definitely if you trigger insulin response it is safe to say you break a fast, but any caloric intake breaks the fast, even without insulin response. "Breaks a fast" is meaningless without specifying what we mean by that. If we mean "breaking fast = you eat something with calories" then yes, but then it's a tautology. If we mean "insulin response", then there would be other criteria for breaking a fast. Even tradit…

>Breaks a fast" is meaningless without specifying what we mean by that. If we mean "breaking fast = you eat something with calories" then yes, but then it's a tautology.

Yes...that is how definitions work. Consuming calories triggers a metabolic response and breaks a fast. That is the generally accepted definition of breaking a fast.

There are types of fasts dry fast, water fast, intermittent fast. But the fast part is consistent and means no calories/no metabolic response.

The idea some religion somewhere ate plants only a called it a fast, doesn’t make it a fast. If I consume nothing but sugar and went around calling it a sugar fast, that doesn’t change the definition of fast. Similarly if you have a diet that doesn’t trigger insulin, that is a Dietary ketosis. If you are fasting you will also enter ketosis but since it’s induced through fasting not diet we call it fasting ketosis.

Re: Eating in 10-hour window can override disease-causing genetic defects

#66

Post by laurex »

The comparison was between rats who could eat anytime and rats eating within a 10 hour window. What makes 10 hours the magic? Could it be 11, 12, 14 hours? Is it better if the window is 6 or 8 hours? Would it be different on a day in which the sun shone for 16 hours or 12 his? There is clearly something there but 10 hours seems arbitrary.

Re: Eating in 10-hour window can override disease-causing genetic defects

#67

Post by coldtea »

nickjj wrote: post #64
coldtea wrote: post #58

Earlier quoted context omitted.

> Wouldn't you have to really go out of your way to deviate from that? Depends on the country and culture. In these here parts we still go to work at 8am or 9am, but we dine at 10pm or later (going to a restaurant at 11pm is very common, and similarly for eating at home).

What time do you get home from work? That sounds like an unreasonably long day if you have to be in work by 8am but you're still at a restaurant at 11pm. I'm from the US btw. I happen to do freelance work but most people I know work from about 9am to 5pm where they leave the house around 8:30am and are home by 5:30pm or 6pm at the latest. Eating breakfast at 8am and dinner at 7pm is normal for them, or sometimes they…

>What time do you get home from work?

Depends on the job. Office jobs are nominally 9-5 but it's easy for employees to stay until 7pm or so in some places. Retail shops (anything from butchers and grocery places to supermarkets and shoe shops and electronics shops) close at 8-8:30pm (they usually open around 9am or a little later) -- but those have shifts too (e.g. those working there don't stay all day from 9am to 8:30pm, unless they're the owners).

Some places (usually the self-run ones) also close around 2:30/3:00pm and open again at 5:30pm or so.

>That sounds like an unreasonably long day if you have to be in work by 8am but you're still at a restaurant at 11pm.

Not "still at the restaurant at 11pm" - it's first sitting down at the restaurant at 11pm (they'd leave at 12:30 - 1am or so). They I guess you sleep for 6-7 hours or so and wake at 7 or 8.

Re: Eating in 10-hour window can override disease-causing genetic defects

#68

Post by coldtea »

will_brown wrote: post #65
coldtea wrote: post #57

Earlier quoted context omitted.

> Definitely if you trigger insulin response it is safe to say you break a fast, but any caloric intake breaks the fast, even without insulin response. "Breaks a fast" is meaningless without specifying what we mean by that. If we mean "breaking fast = you eat something with calories" then yes, but then it's a tautology. If we mean "insulin response", then there would be other criteria for breaking a fast. Even tradit…

>Breaks a fast" is meaningless without specifying what we mean by that. If we mean "breaking fast = you eat something with calories" then yes, but then it's a tautology. Yes...that is how definitions work. Consuming calories triggers a metabolic response and breaks a fast. That is the generally accepted definition of breaking a fast. There are types of fasts dry fast, water fast, intermittent fast. But the fast part…

>The idea some religion somewhere ate plants only a called it a fast, doesn’t make it a fast.

Actually it does.

It might not make it "a period of no food consumption at all", but it does make it a fast.

It's not the etymology or scholarly definition of words that dictates their meaning, but how they are actually used by the people speaking a language.

The word fast (and it's analogous in different languages) has been in use for centuries/millennia longer than people actually knowing what a "metabolic response" is -- so such a concern couldn't be part of how they used the term unless until very recently.

As Wikipedia puts it: "Fasting is the willing abstinence or reduction from some or all food, drink, or both, for a period of time".

Notice the "some or all food"?

Here's how the fast period is defined for catholics for example:

"For Roman Catholics, fasting, taken as a technical term, is the reduction of one's intake of food to one full meal (which may not contain meat on Ash Wednesday and Fridays throughout Lent) and two small meals (known liturgically as collations, taken in the morning and the evening), both of which together should not equal the large meal. Eating solid food between meals is not permitted. Fasting is required of the faithful between the ages of 18 and 59 on specified days. Complete abstinence of meat for the day is required of those 14 and older. Partial abstinence prescribes that meat be taken only once during the course of the day. Meat is understood not to include fish or cold-blooded animals."

Re: Eating in 10-hour window can override disease-causing genetic defects

#69

Post by stochastic_monk »

I’ve experimented with intermittent fasting, carb cycling, and a variety of other methods.

Intermittent fasting’s benefits for me are primarily the lack of distraction and fluctuations in my blood glucose level. I found that consuming protein or fats in the morning does not affect the latter benefit. It seems to me that it’s more about a diet that’s easy to stick to than dramatically altering one’s metabolism.

Lately, I’ve become more serious about strength training and have given up on it because my caloric needs have skyrocketed (I found myself losing weight at over 3000 calories a day.) and I need to eat frequently to recover.

However, I would not hesitate to recommend it to anyone who isn’t an athlete, and to the latter I’d still suggest experimenting.

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