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Eating in 10-hour window can override disease-causing genetic defects

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Re: Eating in 10-hour window can override disease-causing genetic defects

#41

Post by ainar-g »

projectramo wrote: post #8

Another major victory in mankind’s long quest to render mice immortal.

For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight:

>After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a dose 500 times smaller than that found safe in animal studies, all six human volunteers faced life-threatening conditions involving multiorgan failure for which they were moved to intensive care unit

Source[2].

[1] https://www.youtube.com/watch?v=zvJHq2FJPDM

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964774/

Re: Eating in 10-hour window can override disease-causing genetic defects

#43

Post by pizza234 »

SwellJoe wrote: post #23

I've been on an intermittent fasting schedule (I usually do 16/8) for about a year and a half. I lost some weight during the first several months, but have leveled off to a reasonable weight (which is probably 10 pounds heavier than I'd like, but ~25 pounds lighter than when I started intermittent fasting). Overall, I don't see any dramatic changes. Lots of people claim to see a significant difference, usually positi…

> Lots of people claim to see a significant difference, usually positive, in energy, strength, mood, sleep, etc.

I'm very skeptical of people's dieting claims in general.

First, lots of people, more or less unconsciously, omit their previous condition/background.

A typical example of this (that tragically gets always attention on HN) is an obese person making a post about how they made change X and lost Y kgs. When you're obese because of bad habits, any minimal healthy change will lead to weight loss.

Second, every [not seriously into sports] person I ever spoke to who applied a change in his/her nutrition, reported the same symptoms (more energy, better sleep, etc.etc.), independently of how absurd the change was.

Considering also how extremely variable between samples (=people) lifestyle is, the only reasonable way I accept is just to set emphasis on personal metrics and disregard other people's experience (I actually assume the vast majority of them to be inaccurate to the point of being false, for the above reasons).

Re: Eating in 10-hour window can override disease-causing genetic defects

#44

Post by grecy »

browsercoin wrote: post #27

Is it possible that with economic affluence of the West, overconsumption is harmful? It used to be that there would be days where our ancestors would not be able to bring home any meat so fasting probably was built in as part of our metabolism process. It was only in the past 100 years that we've seen mass produced sugary food and drinks. Like the diet difference is painfully obvious when you go to Japan's 7-11. Heal…

> Is it possible that with economic affluence of the West, overconsumption is harmful?

Absolutely. As Michael Pollan points out, our food has changed more in the last 50 years than it did in the preceding 5000, in both composition and quantity.

There is no way we have adapted that fast.

Re: Eating in 10-hour window can override disease-causing genetic defects

#45

Post by DoreenMichele »

SwellJoe wrote: post #23

I've been on an intermittent fasting schedule (I usually do 16/8) for about a year and a half. I lost some weight during the first several months, but have leveled off to a reasonable weight (which is probably 10 pounds heavier than I'd like, but ~25 pounds lighter than when I started intermittent fasting). Overall, I don't see any dramatic changes. Lots of people claim to see a significant difference, usually positi…

But, I'm also at the age where the effects of aging begin to be noticeable...so, maybe just maintaining levels is progress?

The thing is we can't clone you multiple times and treat each replica of you differently, so we have no idea if you would be terribly sick or something by now if you had made other choices.

I'm always fascinated by anecdotes about fasting, etc. But it's actually incredibly hard to isolate one dietary factor and draw firm conclusions about cause and effect.

From what I gather, large scale longitudinal studies are our best data for diet in humans and they conclude things like "A handful of nuts a day is good for you."

Re: Eating in 10-hour window can override disease-causing genetic defects

#46

Post by Retric »

j7ake wrote: post #36
projectramo wrote: post #8

Another major victory in mankind’s long quest to render mice immortal.

You're suggesting that mouse studies are not useful because they do not apply to humans are overly cynical. You're not giving enough credit to the similarities between mice and humans in physiology. These time restricted feeding studies have been done in humans with effects in the same direction. https://www.sciencedirect.com/science/article/pii/S155041311...

For studies that are easy and safe to conduct in humans testing in mice seems largely pointless. Sure it might cost far less, but the data is also far less useful.

It’s the reverse that’s then useful. If you can find an animal model that replicates a known human result then you can investigate the mechanics more easily. Ex: Scurvy

Re: Eating in 10-hour window can override disease-causing genetic defects

#47

Post by nickjj »

I'm kind of surprised this isn't the default for most people.

For example let's say you eat dinner at 6-7pm and then goto bed at 11pm. After that you wake up around 7am and then maybe eat breakfast an hour or 2 later.

At this point you've gone from about 7pm to 8am or 9am without eating (~13-14 hours) but it fits pretty well into a schedule.

Wouldn't you have to really go out of your way to deviate from that? Of course you would adjust the numbers based on how late you goto bed and rise in the morning, but the ratios would be about the same -- maybe even more fasting if you sleep longer than 8 hours.

Re: Eating in 10-hour window can override disease-causing genetic defects

#48

Post by throwaway66666 »

oh_sigh wrote: post #40
throwaway66666 wrote: post #31

I 've spent 3.5/4 years eating nothing except on the weekends (my undergrad). So I would go for 2-5 days at a time without food. Not because of fasting fads or anything, I didn't even know what fasting was. I was just from a very poor family and if I wanted to go for vacations with my friends or party in the weekend or buy a computer I had to save every penny I could. (that's how I bought my first laptop etc). I woul…

It sounds like you were just starving yourself. I'm going to guess that you weren't eating 2-5 days worth of food whenever you chose to eat? I'm sorry but going that long without eating just doesn't make any sense. Did you/your family only have the ability to buy/acquire one meal at a time or what?

No, I was living alone while going to school. I would starve myself so I could save more money. What is the difference between X day fasts and what I did?

I am not trying to claim that fasting doesn't work, just noting my personal experience. For me it certainly worked in the sense that I saw the fakeness of "if you don't eat for X days you get super hungry or weak/sick/you die", I was perfectly ok.. but not amazing.

Re: Eating in 10-hour window can override disease-causing genetic defects

#49

Post by jvvw »

nickjj wrote: post #47

I'm kind of surprised this isn't the default for most people. For example let's say you eat dinner at 6-7pm and then goto bed at 11pm. After that you wake up around 7am and then maybe eat breakfast an hour or 2 later. At this point you've gone from about 7pm to 8am or 9am without eating (~13-14 hours) but it fits pretty well into a schedule. Wouldn't you have to really go out of your way to deviate from that? Of cour…

That implies eating breakfast at work for most people. Also you need to be leaving work promptly at 5pm, not have too long a commute home and then start cooking straight away if you want to eat dinner by 6.30pm. (I do this, but didn't pre-kids, and don't think it fits by default into most people's lives).

Re: Eating in 10-hour window can override disease-causing genetic defects

#50

Post by zeroimpl »

jayzee44 wrote: post #37
zeroimpl wrote: post #24

Did the mice which had access to food 24/7 eat more overall than the mice with restricted food access? If so, then the study seems useless because the results can entirely be explained as excessive eating leads to health problems. I don't see anything in the article saying how they controlled for quantity of food consumed.

No the article said that's both groups consumed the same number of calories per day.

Thanks. I didn't read it carefully enough the first time but I see that mentioned now.
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