Earlier quoted context omitted.
reddit uses something like 250-300 EC2 nodes.
Unless they are using the really big instances though, I find that EC2 nodes are generally lower in power compared to what most people are using for their servers. I remember not too long ago before they moved to EC2 everything fit in just a few racks. Of course, their traffic has expanded significantly recently.
A lot of the "web scale" noise has come from dealing with these gerbil sized instances.