Earlier quoted context omitted.
I would suggest the quality of the drug matters far more than the digestive system. And that the difference between first-time experience and hundredth-time (which I don't think is a particularly healthy number of times to hit) is quite large.
Well, I would not suggest that since in most of the settings I had participated, people would be taking the powder from the same source. So I’ve got a feeling that your point comes from reading some info on the internet, rather than your own experience.
I can't believe I'm saying this on HN, looks like it's finally just another subreddit: I have plenty experience, sure.