GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

Post by beaugunderson » Wed, Jul 25, 2018, 10:03 PM UTC

breck wrote: post #43

dayvid wrote: post #24

I asked 23andMe if there was any way to delete my genetic data from their site after the Equifax hack news. From their response: "23andMe and our third party genotyping laboratory will retain Genetic Information, date of birth, and sex as required for compliance with applicable legal obligations, including the U.S. Federal Clinical Laboratory Improvement Amendments of 1988 (CLIA), California Business and Professional…

I believe there are services that will do whole genome seq for you for under $10k(and I assume won’t keep your data). You could then use Promethease for analysis. I’m unaware of any way you could do self-DNA testing at home unless you wanted to spend $100k+ on equipment, reagents, etc. The Nanopore might be relevant but I haven’t looked into it much.

Post by reaperducer » Wed, Jul 25, 2018, 10:11 PM UTC

aaavl2821 wrote: post #52

TrainedMonkey wrote: post #3

Make no mistake about what is happening here. GSK is buying access to all of the genetic data that 23andMe has. This is why I am wary to use any 23andMe type of service. "The partners plan to use 23andMe’s data to jointly discover drug targets." They will claim all kinds of protections of course, but it is only a matter of time until genetic data starts being resold.

Using genetic data to find new drugs strikes me as a very good use of this data. Medical data is essential to the process of finding new drugs and treating patients and is highly regulated. I think you're right to be concerned about sharing of genetic data, but conflating facebook / google data sharing practices with medical data sharing is not appropriate If the concern is that 23and me may bring the google / FB app…

Post by jryan49 » Wed, Jul 25, 2018, 10:18 PM UTC

joering2 wrote: post #121

jryan49 wrote: post #97

I see a lot of people making claims about 23andme that haven't used the product, and I just wanted to inform people that in the contract you sign with them, they only share your data if you opt-in to it. They make this all very clear. You can also have them discard your sample and delete your info if you haven't opt-ed in to the research program. Now trusting that 23andme is actually abiding by these rules is a diffe…

Have you EVEN read the title?? They are not sharing this information with private entity aka. opt-in/out. They made partnership research & development agreement in with GSK with invest over $300MM. 23and me is not sharing our data outside their fences BUT this agreement will let them bring GSK into their playground and do all sorts of stuff with your DNA. Worst case they will just buy the whole 23andMe as a company a…

Post by reaperducer » Wed, Jul 25, 2018, 10:23 PM UTC

nradov wrote: post #38

mcculley wrote: post #23

Earlier quoted context omitted.

I don't understand these concerns. I have published my data from 23andMe ( https://enki.org/2017/10/17/publishing-my-genome/ ) ( https://github.com/mcculley/genes-genes ). Can you share what you think the bad outcomes would be? What am I missing? Edit: As people bring up the insurance risk, yes I did consider that and mention it in my post. I am personally not concerned about it and think the advantages outweigh the…

In the USA the Genetic Information Nondiscrimination Act of 2008 explicitly prohibits discrimination on the basis of genetic information with respect to health insurance and employment. No one in politically powerful positions has seriously advocated for repealing the law. The insurance companies don't even dislike it because it creates a level playing field; since the market is competitive, even if they were allowed…

Post by Retric » Wed, Jul 25, 2018, 10:31 PM UTC

ig1 wrote: post #109

Retric wrote: post #53

Earlier quoted context omitted.

Plenty of other risks. Once you get into the X million+ sample ranges false positives for paternity tests or criminal cases become likely. 10 million tests vs 10 million person database means 1 in 10 trillion false positives happen 10 times.

That's not how it works, the chances of two people matching as identical (on the SNP tested by 23andme) by random is astronomically low - orders of magnitude higher than the total number of humans who've ever lived. Generally at a 7cM overlap you have 50:50 chance whether you're related to that person or not. Anything over say 150cM you're virtually certain to be related (ignoring endogamous populations). At 3,400cM…