Earlier quoted context omitted.
I don't understand these concerns. I have published my data from 23andMe ( https://enki.org/2017/10/17/publishing-my-genome/ ) ( https://github.com/mcculley/genes-genes ). Can you share what you think the bad outcomes would be? What am I missing? Edit: As people bring up the insurance risk, yes I did consider that and mention it in my post. I am personally not concerned about it and think the advantages outweigh the…
Are you part of the Personal Genome Project? It's a large community of people who share their genetic data for science. http://www.personalgenomes.org/us
GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
51–60 of 228 posts
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#52Make no mistake about what is happening here. GSK is buying access to all of the genetic data that 23andMe has. This is why I am wary to use any 23andMe type of service. "The partners plan to use 23andMe’s data to jointly discover drug targets." They will claim all kinds of protections of course, but it is only a matter of time until genetic data starts being resold.
I think you're right to be concerned about sharing of genetic data, but conflating facebook / google data sharing practices with medical data sharing is not appropriate
If the concern is that 23and me may bring the google / FB approach to personal data to healthcare then i share your concern
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#53Earlier quoted context omitted.
I don't understand these concerns. I have published my data from 23andMe ( https://enki.org/2017/10/17/publishing-my-genome/ ) ( https://github.com/mcculley/genes-genes ). Can you share what you think the bad outcomes would be? What am I missing? Edit: As people bring up the insurance risk, yes I did consider that and mention it in my post. I am personally not concerned about it and think the advantages outweigh the…
I’ve also done 23andme and am open about my data. I can think of about 3 negative outcomes (maybe insurance problems that could occur without regulation; family privacy issues if someone wanted to track you or a family member down; annoying advertising), and about 1,000 positive outcomes (contributing data to help cure cancer, predict disease susceptibility, drug response, improve general health and wellness, et cete…
10 million tests vs 10 million person database means 1 in 10 trillion false positives happen 10 times.
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#54Earlier quoted context omitted.
I’ve also done 23andme and am open about my data. I can think of about 3 negative outcomes (maybe insurance problems that could occur without regulation; family privacy issues if someone wanted to track you or a family member down; annoying advertising), and about 1,000 positive outcomes (contributing data to help cure cancer, predict disease susceptibility, drug response, improve general health and wellness, et cete…
Plenty of other risks. Once you get into the X million+ sample ranges false positives for paternity tests or criminal cases become likely. 10 million tests vs 10 million person database means 1 in 10 trillion false positives happen 10 times.
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#55Make no mistake about what is happening here. GSK is buying access to all of the genetic data that 23andMe has. This is why I am wary to use any 23andMe type of service. "The partners plan to use 23andMe’s data to jointly discover drug targets." They will claim all kinds of protections of course, but it is only a matter of time until genetic data starts being resold.
> genetic data starts being resold Or hacked.
Is the hacker going to call me up and suggest I start taking high blood pressure medication?
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#56I asked 23andMe if there was any way to delete my genetic data from their site after the Equifax hack news. From their response: "23andMe and our third party genotyping laboratory will retain Genetic Information, date of birth, and sex as required for compliance with applicable legal obligations, including the U.S. Federal Clinical Laboratory Improvement Amendments of 1988 (CLIA), California Business and Professional…
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#5723andme has made a pretty impressive recovery after the FDA issues a few years ago, although i think the jury is still out on how useful their data will be for drug discovery. I think they mostly have genotype data rather than WES, and i think their clinical data is all patient reported? The value of their engaged audience seems clearer, especially if it can help enroll clinical trials faster
It may be that GSK isn't really interested in the existing 23&me product line, but wants their name recognition and infrastructure. 23 is as close as anyone to delivering a full GWAIS product to the public, which this partnership only enhances. Combined with large capacity cheap deep sequencing by someone like BGI, this partnership would be ideal for GSK to add in-house infrastructure to do a LOT of GWAIS for all kin…
I'm less convinced of the value of 23 and me data in drug discovery. It could be quite useful but is not best in class. The regeneron genetics center is a much better approach imo -- sequencing data vs genotyping, access to robust medical data, partnerships with leading medical institutions to get patients and data, and a targeted biology driven strategy that reduces the cost of getting a signal. As far as cost per good potential target, 23and me is probably an order of magnitude or more behind
Not sure how 23 and me would help GSK analyze genetic subpopulations -- GSK could sequence patients just fine on their own without 23and me and get more robust data than 23 and me genotype data. For biomarker discovery once you have a candidate and are moving into clinical studies there are probably much better targeted solutions than 23 andme
Value of 23 and me is 1) brand and 2) data on large number of pts. 2) helps with finding genetic markers with low effect size which isn't really helpful for drug discovery and also finding rare variants with large effect, which is important, but there are better / cheaper ways of doing that (i.e. regeneron)
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#58Earlier quoted context omitted.
In the USA the Genetic Information Nondiscrimination Act of 2008 explicitly prohibits discrimination on the basis of genetic information with respect to health insurance and employment. No one in politically powerful positions has seriously advocated for repealing the law. The insurance companies don't even dislike it because it creates a level playing field; since the market is competitive, even if they were allowed…
Would that act cover things like targeting health insurance ads based on genetic traits? How about displaying recruitment ads to people with lactose tolerance gene, effectively excluding most of worlds non-white population?
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#59I asked 23andMe if there was any way to delete my genetic data from their site after the Equifax hack news. From their response: "23andMe and our third party genotyping laboratory will retain Genetic Information, date of birth, and sex as required for compliance with applicable legal obligations, including the U.S. Federal Clinical Laboratory Improvement Amendments of 1988 (CLIA), California Business and Professional…
Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact
#60Make no mistake about what is happening here. GSK is buying access to all of the genetic data that 23andMe has. This is why I am wary to use any 23andMe type of service. "The partners plan to use 23andMe’s data to jointly discover drug targets." They will claim all kinds of protections of course, but it is only a matter of time until genetic data starts being resold.
I don't understand these concerns. I have published my data from 23andMe ( https://enki.org/2017/10/17/publishing-my-genome/ ) ( https://github.com/mcculley/genes-genes ). Can you share what you think the bad outcomes would be? What am I missing? Edit: As people bring up the insurance risk, yes I did consider that and mention it in my post. I am personally not concerned about it and think the advantages outweigh the…