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Psychedelics Promote Structural and Functional Neural Plasticity

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Re: Psychedelics Promote Structural and Functional Neural Plasticity

#11
post #7

I’m a huge proponent of safe psychedelic use, specifically LSD. I was massively depressed and suicidal growing up (I had family problems, and two of my best friends killed them selves at 13 and 17). I dropped out of high school. I experimented with LSD and mushrooms around 17/18 years old. And while I didn’t realize it then, my life massively changed for the better. Maybe I grew up. Maybe I took responsibility for my…

So how do I get to experiment with this in a controlled and legal way these days?

step one is realizing that if you want to expand your mind you have to reject the systems of control that dictate to you which thoughts and behaviors are allowed.

put differently: the barriers to experimentation with psychedelics are the ones that you have constructed for yourself.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#12
I am overall pro psychedelics but I have seen them harm people first hand as well. They should be treated with a lot of caution and respect. I totally understand the urge to evangelise them but keep in mind that you're taking on a lot of responsibility when you encourage people to experiment with their brain chemistry.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#13
post #7

I’m a huge proponent of safe psychedelic use, specifically LSD. I was massively depressed and suicidal growing up (I had family problems, and two of my best friends killed them selves at 13 and 17). I dropped out of high school. I experimented with LSD and mushrooms around 17/18 years old. And while I didn’t realize it then, my life massively changed for the better. Maybe I grew up. Maybe I took responsibility for my…

So how do I get to experiment with this in a controlled and legal way these days?

You don’t.

But if you have the drive, and are willing to take a small risk, you venture into the dark web and locate one of the handful of chemists/dealers who provide the world with its supply and buy in bulk.

Or you find a friend who has already done this work.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#14
post #5

For those that haven't tried psychedelics but are curious about them in a personal growth / non-recreational way, on the Joe Rogan podcast I heard a good metaphor along these lines: Imagine your brain as a snowy hill. Each decision you make is like sledding down the hill, causing a slight indentation in the snow. The more times you make a decision, the deeper the groove, the faster you make the decision and the harde…

It's not a bad analogy. I will add this: the shape of the hill stays the same, and mostly that fresh powder will melt back into those old ruts... the changes that these experiences bring seem, to me, more about knowing the ruts are there then they are about changing things in our lives. The change comes from the awareness of what can be done, because formerly "natural" things that are "just what people do" start to s…

yeah, one of the biggest misconceptions that i had was that it would be "fun" to try psychedelics. it wasn't fun, and it wasn't not-fun. it was different, and it was a learning experience.

the long lasting effects were negligible for me. the biggest change was that i realized i might be "on the spectrum" but it isn't as though it was a life-changing realization.

i agree regarding your final point. i do think that psychedelics are more "helpful" for people who are extremely extraverted or otherwise reluctant to reflect on themselves.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#15

I am overall pro psychedelics but I have seen them harm people first hand as well. They should be treated with a lot of caution and respect. I totally understand the urge to evangelise them but keep in mind that you're taking on a lot of responsibility when you encourage people to experiment with their brain chemistry.

I hear ya. I’ve yet to see it negatively effect anyone other than a bad trip, which, seen in the right light, can be a therapeutic experience.

But I know they need to be respected and understood.

I also realize that some people with a family history of mental disorders like schizophrenia, would be better off staying away.

Like, some people have used psychedelics, and they go crazy. But how many of those people were crazy to begin with? How many would end up like that if they never tried psychedelics to begin with?

I tend to think that the fear is over dramatized.

But I do emphasize respecting its use in a profound way.

It changes you.

The upside is that real LSD is so rare, the chances of people finding it are slim to non. It’s distributed by so few people.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#16
post #4
post #2

Current antidepressant drugs are garbage by comparison but we're stuck with them for profit and stupidity reasons. In the meantime millions who could potentially be helped suffer and die. It's truly hard to justify the current situation on this research and the government's position in letting people suffer and die from such a horrific condition as depression when there might be a solution right before our eyes. Futu…

Yes it seems totally plausible that psychedelics can help people who had maladaptive experiences or upbringings make permanent improvements, that symptom relief drugs like antidepressants may even stand in the way of. Almost all of the work on using psychedelics to treat trauma bears this out. On the other hand, if psychedelics increases plasticity, regular use could also destabilize a mind or erode important learnin…

>psychedelics can help people who had maladaptive experiences or upbringings make permanent improvements, that symptom relief drugs like antidepressants may even stand in the way of.

this is my understanding as well. kind of like how a child would never learn how to walk on its own if the parent held it upright 100% of the time.

unfortunately, i think a big problem with the current standard of care is that it prioritizes shutting the patient up -- reducing complaints regarding symptoms -- over curing the patient.

there is a difference; imagine if the "real" effect antidepressants have is to make people more reluctant to communicate negative thoughts to others. the patient would still be suffering just as much, but appear to have improved. the brain is subtle enough for this to be a reality...

obviously i don't believe that this example (which is totally made up) is uniformly the case. but shifting the frame to address the underlying problem of "stuck" or maladaptive neural circuitry via psychedelics could be immensely helpful for patients.

psychedelics would also improve the efficacy of the other psychoactive tool we kind of think is somewhat helpful in some instances of some kinds of cases: therapy. therapy is retooling neural circuitry the hard way -- via repeated activation of alternative thought patterns of nebulous physiology in the hopes of eventually shifting the thought pattern to be adaptive rather than maladaptive. if we had a switch to flip that would enhance neural plasticity, this process would be much faster and much more effective. it would also be much more fraught with chances of inflicting damage, i'd assume.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#17

I am overall pro psychedelics but I have seen them harm people first hand as well. They should be treated with a lot of caution and respect. I totally understand the urge to evangelise them but keep in mind that you're taking on a lot of responsibility when you encourage people to experiment with their brain chemistry.

I hear ya. I’ve yet to see it negatively effect anyone other than a bad trip, which, seen in the right light, can be a therapeutic experience. But I know they need to be respected and understood. I also realize that some people with a family history of mental disorders like schizophrenia, would be better off staying away. Like, some people have used psychedelics, and they go crazy. But how many of those people were c…

I watched a good friend freak out in front of me on a bad trip. Almost thirty years later he's still not the same and needs antipsychotic medication to function. This kind of thing isn't common but it can definitely happen.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#18

Earlier quoted context omitted.

So how do I get to experiment with this in a controlled and legal way these days?

You don’t. But if you have the drive, and are willing to take a small risk, you venture into the dark web and locate one of the handful of chemists/dealers who provide the world with its supply and buy in bulk. Or you find a friend who has already done this work.

Thank you for the info

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#19
post #7

I’m a huge proponent of safe psychedelic use, specifically LSD. I was massively depressed and suicidal growing up (I had family problems, and two of my best friends killed them selves at 13 and 17). I dropped out of high school. I experimented with LSD and mushrooms around 17/18 years old. And while I didn’t realize it then, my life massively changed for the better. Maybe I grew up. Maybe I took responsibility for my…

So how do I get to experiment with this in a controlled and legal way these days?

I am curious about that too.

Re: Psychedelics Promote Structural and Functional Neural Plasticity

#20

Earlier quoted context omitted.

I hear ya. I’ve yet to see it negatively effect anyone other than a bad trip, which, seen in the right light, can be a therapeutic experience. But I know they need to be respected and understood. I also realize that some people with a family history of mental disorders like schizophrenia, would be better off staying away. Like, some people have used psychedelics, and they go crazy. But how many of those people were c…

I watched a good friend freak out in front of me on a bad trip. Almost thirty years later he's still not the same and needs antipsychotic medication to function. This kind of thing isn't common but it can definitely happen.

It's entirely possible that LSD uncovered or accentuated an underlying flaw in your friend's psyche...
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