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It's not common. My site with hundreds of thousands of users has been using React/Vue for years and I've never had one complaint about JavaScript. If JavaScript is disabled I just show a message saying the site needs it. I also only support modern browsers and haven't had a complaint for 3 years. About 3 months ago I completely dropped support for any browser that doesn't support CSS grid (no more IE 11!). Again, no…
How does your site sound/read in a screenreader like NVDA? [0] 0: https://www.nvaccess.org/
I haven't tested myself (I'm just one dude - there's a lot I'd like to do but haven't yet), but I see no reason why it wouldn't work well. I try to design semantically and everything is rendered server-side.
But, in reality, I don't think this is the kind of website that would be usable for a blind person anyway. There's not really anything to read. There would be much better ways for a blind person to get information than using this website.