'Unique' cannabis compound reverses brain aging in mice • Hacker News Board

Re: 'Unique' cannabis compound reverses brain aging in mice

#71

Post by krageon » Wed, Jun 27, 2018, 11:48 AM UTC

darkerside wrote: post #36

krageon wrote: post #26

Earlier quoted context omitted.

That sort of question is highly personal. I've heard many, many people espousing the virtues of some strain of weed or other (eg claiming it helps you think and doesn't make you fall asleep so much) but I've never actually found one that doesn't primarily make me sleepy. I do have access to an enormous variety to try (and I've definitely done my due diligence, so to speak). This has led me to believe that for some pe…

I wonder if it could be a dosing issue? That said, everyone's brain is different.

I've tried it with tinctures as well as a host of other things. A tincture is nice because it allows for fairly exact dosing, but for me it appears to range from "0 effect" to "some effect, and that effect is drowsy" all the way up to "you're going to sleep now".

Re: 'Unique' cannabis compound reverses brain aging in mice

#72

Post by slfnflctd » Wed, Jun 27, 2018, 11:50 AM UTC

lawlessone wrote: post #56

lwansbrough wrote: post #11

Earlier quoted context omitted.

Smoke less is good advice. But also, if you’re prone to panic attacks, try giving yourself one intentionally (when you’re sober) when you feel you’re in a good environment. Learning to mentally overcome panic attacks is probably one of my greatest accomplishments in life. Now when I feel one onsetting, I can completely come down from it. The key is in remembering two things: you’re actually going to be fine, and you’…

How on earth do you intentionally give yourself a panic attack?

Yeah, I raised my eyebrows at that one too. I'm pretty sure I had the first one of my life recently and still am not certain what caused it.

I suddenly was getting massively winded with the simplest physical activity. The only reason I didn't think it was a breathing or heart problem was that my S.O. recognized the symptoms and theorized it was anxiety. About 15 minutes after taking a beta blocker those symptoms disappeared, proving the theory correct.

No idea how to re-create it and no desire to, it was kinda scary.

Re: 'Unique' cannabis compound reverses brain aging in mice

#73

Post by rusk » Wed, Jun 27, 2018, 11:51 AM UTC

Broken_Hippo wrote: post #65

SolaceQuantum wrote: post #60

Earlier quoted context omitted.

I don’t think the person above is saying that weed should be banned, just that it has risks that need to be pointed out. See also in this discussion someone pointing out that even small amounts give them panic attacks, and the response had been variously “ok, just given yourself smaller amounts then” and also “have you considered intentionally giving yourself panic attacks” instead of respecting the decision that smo…

Without qualifiers on this stuff, it often reminds me of scare tactics. I did see the bit about panic attacks, and I know it happens - but generally all that is needed for some of this stuff is prudent education. Pointing out, "While most folks tolerate the substance well, some might find it makes a mental or medical condition worse" is considerably different. It is kind of like Ibuprofen or cough and cold medicine.…

Re: 'Unique' cannabis compound reverses brain aging in mice

#74

Post by eddd » Wed, Jun 27, 2018, 11:54 AM UTC

[deleted] wrote: post #24

[deleted]

To me THC helps to find relations between concepts. I can think of any problem from a completely different angle. But,

1. I have to take notes to be able to go back to the line of reasoning.

2. Almost all of the concepts are garbage, but the remaining ones, are the best I've ever had.

So, THC helps to start with an idea, but delivering value from that idea requires being sober.

Re: 'Unique' cannabis compound reverses brain aging in mice

#75

Post by kaybe » Wed, Jun 27, 2018, 11:58 AM UTC

thefounder wrote: post #62

YeGoblynQueenne wrote: post #27

If progress in technology continues at this pace, in a few years we will be able to indefinitely extend the life of mice.

We still don't have flying cars....so I would't bet that much on the tech progress. Maybe in 100+ years we will get something close but I doubt we will discover immortality any time soon.

It's called a helicopter. Turns out it's very impractical and wasteful for everyday use.

Re: 'Unique' cannabis compound reverses brain aging in mice

#76

Post by arpa » Wed, Jun 27, 2018, 12:00 PM UTC

tzahola wrote: post #4

Too bad it gives me panic attacks.

I have been smoking for some ten years, and a few years back i started becoming afraid of getting high. It's no help that my country is ridiculously behind the times - you can get up to eight years in prison just for having cannabis on you, regardless of amount (and hey, we're in the EU, who would have thought!) - but the thing is that it really becomes very easy to go on a very unpleasant tangent, start overthinking, overanalysing, worrying and finally panicking about things - and my "panic pony" is my job. Once I start thinking about it, it's almost always a guarantee of a bad experience. So I started getting "afraid of getting afraid", and significantly cut down my cannabis use to, well, near zero: I still use it socially maybe once a year or two. However, even though I am a very occasional user, I found that anxiolytics such as xanax in small doses offset the paranoia pretty well. Also, edibles are much more mellow in my experience - you are not just "thrown" into the state, but rather edged into it, and it gives you better control.

oh and also, as with all psychedelics - set and setting are very, very, very important.

well that's my story.

Re: 'Unique' cannabis compound reverses brain aging in mice

#77

Post by acct1771 » Wed, Jun 27, 2018, 12:06 PM UTC

krageon wrote: post #66

acct1771 wrote: post #57

Earlier quoted context omitted.

Have you ever tried a low dosage via vaporization? Smoking itself, because of carcinogens and oxygenation, will lead you to the sluggishness many people associate with kush. Fuck smoking. /rant

I've tried a low dosage via vaping yes. It still made me drowsy. I can't really smoke anything because my lungs respond poorly, so I generally use tinctures/edibles (if I use at all).

Awesome. Well, since we're all trying so hard, I'll throw out one last idea for you: the strain blue dream. One or two hits of that vapor is sufficient for me!

Wishing you the best.

Re: 'Unique' cannabis compound reverses brain aging in mice

#78

Post by acct1771 » Wed, Jun 27, 2018, 12:06 PM UTC

krageon wrote: post #71

darkerside wrote: post #36

Earlier quoted context omitted.

I wonder if it could be a dosing issue? That said, everyone's brain is different.

I've tried it with tinctures as well as a host of other things. A tincture is nice because it allows for fairly exact dosing, but for me it appears to range from "0 effect" to "some effect, and that effect is drowsy" all the way up to "you're going to sleep now".

Combine with a coffee/soda?

Re: 'Unique' cannabis compound reverses brain aging in mice

#79

Post by mberger » Wed, Jun 27, 2018, 12:38 PM UTC

derEitel wrote: post #55

YeGoblynQueenne wrote: post #27

If progress in technology continues at this pace, in a few years we will be able to indefinitely extend the life of mice.

One shouldn't linearly extrapolate science.

Indeed. One would exponentially extrapolate science.

Re: 'Unique' cannabis compound reverses brain aging in mice

#80

Post by SolaceQuantum » Wed, Jun 27, 2018, 12:46 PM UTC

Broken_Hippo wrote: post #65

SolaceQuantum wrote: post #60

Earlier quoted context omitted.

I don’t think the person above is saying that weed should be banned, just that it has risks that need to be pointed out. See also in this discussion someone pointing out that even small amounts give them panic attacks, and the response had been variously “ok, just given yourself smaller amounts then” and also “have you considered intentionally giving yourself panic attacks” instead of respecting the decision that smo…

Without qualifiers on this stuff, it often reminds me of scare tactics. I did see the bit about panic attacks, and I know it happens - but generally all that is needed for some of this stuff is prudent education. Pointing out, "While most folks tolerate the substance well, some might find it makes a mental or medical condition worse" is considerably different. It is kind of like Ibuprofen or cough and cold medicine.…

That person never claimed they were the norm, or even remotely so. They mentioned having plenty of friends who had no ill effects beyond being perceived as lazy by the poster. They shouldn’t have to put a disclaimer on their post saying their negative experience may be an outlier any more than anyone espousing a positive experience should put a disclaimer saying that negative experiences are possible. By arguing that all people espousing negative experiences should also add that they might be outliers, I don’t see how it isn’t merely presenting a skewed view of the situation from the pro-marijuana side.

I should also note that when people have bad experiences with medication like ibuprofen and decide that it isn’t for them, people don’t respond by invalidating their experiences and position in the assumption they just aren’t educated enough about how to use it.