When I graduated college, the job situation wasn't as hot.
I would take a resume, custom tailor a cover letter, change out a few paragraphs in my resume to fit the specific job title --- and then.. no reply -. So. I scripted it. I would scan craigslist, monster, indeed, etc for emails or company names. The script eventually evolved to guess company homepages and scan for emails on 'career' sections.
Based on the job titles it would automatically change out cover letters. It became smart enough to understand that a word doc or txt format resume was required. It could catch "PUT THIS IN THE SUBJECT" and created a queue for hand verification -- otherwise, it would send out the emails. Once they were sent out it would scan incoming emails to determine if there were any leads - and matched the thread together with a unique email footer.
Hilariously, it flipped job searching. I would get long ranting emails why I wasn't a qualified or the position required someone more 'senior' to build CRUD webpages. OH well, HR blew their time, not mine, ---> delete. When a interested company did call, I had a nice mysql database of all the posts that company made and was ready to return a call prepared.
I got a job quickly after this php script starting running.