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Unifying Theories of Psychedelic Drug Effects

ncbi.nlm.nih.gov

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Re: Unifying Theories of Psychedelic Drug Effects

#2
This is a fantastic article and I intend to spend more time reading it in detail.

Articles about psychedelics tend to be either dismissive or full of woo and this takes them seriously as tools to better understand the physical basis of human consciousness.

A major thing I took away from my experience with lsd and mdma was how impossible it seemed that such a small amount of material could so utterly transform my experience of the world.

Anything that does that seems like it must be a powerful tool for understanding what the brain does. I’m glad that scientists and the establishment are finally taking it seriously.

I think the first and second waves of scientific research (as he calls them) ran aground after the early pioneers couldn’t resist evangelizing. The current generation seems to have learned the dangers of becoming another Timothy Leary and have remained clinical and detached in their descriptions.

Re: Unifying Theories of Psychedelic Drug Effects

#6
post #2

This is a fantastic article and I intend to spend more time reading it in detail. Articles about psychedelics tend to be either dismissive or full of woo and this takes them seriously as tools to better understand the physical basis of human consciousness. A major thing I took away from my experience with lsd and mdma was how impossible it seemed that such a small amount of material could so utterly transform my expe…

I'm not sure about that (re: evangelizing). Dr. Shulgin was pretty enthusiastic. I have every book of theirs, autographed. Dr. Nichols is fairly clinical though. I don't know who the up and comers are in the field, but they'll have some huge shoes to fill.

Re: Unifying Theories of Psychedelic Drug Effects

#7
post #2

This is a fantastic article and I intend to spend more time reading it in detail. Articles about psychedelics tend to be either dismissive or full of woo and this takes them seriously as tools to better understand the physical basis of human consciousness. A major thing I took away from my experience with lsd and mdma was how impossible it seemed that such a small amount of material could so utterly transform my expe…

Thats what drugs do, they overwrite the brain patterns to recommend a one size-fits all solution to all problems - more drug - or more drug research. Its called psychological addiction - the you ceases to be, and the it becomes me.

Have i told you how great mdma is. Everyone should try it. I never would have expected that overriding my reward system would reveal my normal life to be such a bland mess and ilusion.

Re: Unifying Theories of Psychedelic Drug Effects

#9
post #2

This is a fantastic article and I intend to spend more time reading it in detail. Articles about psychedelics tend to be either dismissive or full of woo and this takes them seriously as tools to better understand the physical basis of human consciousness. A major thing I took away from my experience with lsd and mdma was how impossible it seemed that such a small amount of material could so utterly transform my expe…

Alcohol is actually quite unique in how it requires such a large dose in order to have an effect. An active dose of ethanol for an average person is somewhere in the realm of 10-50 grams (depending a lot on the size of the person and their tolerance).

Most drugs have an active dose in the <100 mg dose, LSD is particularly low, at <100µg.

Re: Unifying Theories of Psychedelic Drug Effects

#10
It seems like the filtration theory still produced by far the most significant impact to our current understanding of psychedelic effects.

What I was surprised to learn was most research in this domain clearly distinguish adult and non-adult, and the filtration theory implies that kids or younger adults are more creative, have more imaginary freedom, and less emotionally stable - meaning they're naturally more "on drug" - make me wonder if 1 year old really feel like sky-high everyday.

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