I like the toga project in python : https://pybee.org/project/projects/libraries/toga/
Tkinter is terribly integrated and QT hard to install so toga hits a sweet spot. But it's very immature.
My favorite toolkit is still wx, however it just reached V3 compat so it's considered unstable. You can pip install it (well, linux support is so so yet) and all the UI looks native, including the file dialogs.