For me, as a founder of a young startup, the overarching benefit of being proficient in modern JS and sorrounding tooling is that I can use the same language for my whole stack(servers, web, Android, iOS), and spend more time thinking about the product and business. In the possible future where the company grows enough where it needs a distributed server software, the only part of the product that'd be changing would…
(This is also part of the "JS wins" story since two out of those three are ClojureScript, using JS as a compile target)