If you're a target of a major intelligence agency, I think that you have to assume that all of your computers are irretrievably compromised. From Vault 7, we know that the CIA has long developed implants to infect both the EFI and hard drive firmware that load before any potential code that could detect them. These could be made arbitrarily hard to detect without physically opening the computer and dumping these flas…
You may also like to consider that nearly all modern server systems have an iLO/iDRAC or whatever that can do all sorts of things, and at least one internal USB interface. PCs can have the Intel ME and other horrors. The best you can hope for is that it is only your local intel. agency that potentially have routine access to your system.