Earlier quoted context omitted.
I think in this instance DNSSEC would have prevented the entire attack. If I understand the sequence of events correctly, the route hijack was done to the auth DNS servers hosting myetherwallet.com. Then these rogue DNS servers redirected users to a fake myetherwallet.com. If myetherwallet.com had been DNSSEC signed then users who validated the signature chain would have not been redirected to the fake site. But it's…
In a BGP hijacking attack against a DNSSEC-signed zone, the attacker just looks at which IP address is in the signed A record, and then injects that prefix. Note that "the auth servers hosting myetherwallet.com" aren't some random IP addresses in Tallinn, Estonia. It's Route53! I get what you're saying with your counterfactual, that DNSSEC "breaks the exploit", requiring the attackers to use a slightly different expl…
I posted in response to pfg's comment above a mechanism that high value targets could choose, which is modelled on how Facebook behave today but (since we're proving a point here) more extreme. Make a deal with a CA, forbid all other CAs from issuing.
The other thing about Let's Encrypt is that they wouldn't be a good target for such an attacker because they are seeing the world from more than one place. You specify particularly a global BGP hijack, but those are hard, which is why this wasn't global. Tricking just, say, the original San Francisco office of Let's Encrypt doesn't get the job done.