Live data from Hacker News

Ketamine has 'fast-acting benefits' for depression

bbc.co.uk

71–80 of 215 posts

Re: Ketamine has 'fast-acting benefits' for depression

#71
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

That's still cheaper than a private psychologist or psychiatrist (after the initial course).

And public / insurance covered ones are overworked as it is.

Re: Ketamine has 'fast-acting benefits' for depression

#72
post #67
post #63

Earlier quoted context omitted.

I find public health inspectors also make it more expensive to run a restaurant. Perhaps the solution to their tight margins would be to abolish health inspections.

While you're at it, tax makes it more difficult to run a business and making a living. Let us abolish tax as well.

I agree.

Just because a thing exists (the FDA or taxes for instance), doesn't make it a good thing.

Re: Ketamine has 'fast-acting benefits' for depression

#73
post #14
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

Can confirm. I’m in a similar boat. Some other tidbits of information: - only thing that seemed to work even after TMS and other treatments. - New pathways (SF and San Mateo locations) is really good. - more and more treatment places opening up in different cities etc. - uber assist or drive the patient home (full lucidity afterwards but you don’t want to drive). - long-term benefits aren’t apparent after the first t…

Where are you getting this treatment from? Did you directly ask for it?

Re: Ketamine has 'fast-acting benefits' for depression

#74

> The nasal spray is now undergoing phase three trials before it can be licensed for treatment. Can anyone comment on how long it might take for it to hit the market, from this stage?

In some countries in Europe it's already possible for a psychiatrist to request (legally) such preparation from a pharmacy and they will prepare it. Legend has it some first responders are carrying ketamine nasal sprays as a first help for depressed people wanting to commit suicide. I wonder if it's true.

Re: Ketamine has 'fast-acting benefits' for depression

#75

If you're an American, every time you read a new article on Ketamine for depression your thought should be "Jeese, healthcare is screwed up". Pharma companies don't benefit from getting Ketamine approved (since it's no longer patent protected), so no one is putting it through FDA for depression. As a result insurance will never cover it (under the current model). The reason this treatment isn't mainstream isn't becau…

A pair of researchers told me the same about cannabidiol.

Re: Ketamine has 'fast-acting benefits' for depression

#76
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

Doesn't ketamine stimulate growth in the same areas of the brain that exercise does, and does therapy prescribe routine daily exercise? I can imagine there being a great short term benefit to ketamine, as people who are severely depressed can't exercise due to the depression. Has there been any mention switching from ketamine to daily exercise, or doing both?

The difference is that ketamine shows positive results in clinical trials (even for severe depression) while exercise doesn't, unless you include poor quality trials and you limit results to mild depression.

Re: Ketamine has 'fast-acting benefits' for depression

#77
post #67

Earlier quoted context omitted.

While you're at it, tax makes it more difficult to run a business and making a living. Let us abolish tax as well.

I agree. Just because a thing exists (the FDA or taxes for instance), doesn't make it a good thing.

Wow look, an ancap in 2018!

Re: Ketamine has 'fast-acting benefits' for depression

#78
In the late 90s/early 2000s, I went to a lot of raves and everyone who partied and took club drugs used ecstasy and ketamine regularly, often in combination.

A lot of people that I used to hang out with back then are on a private email list now, where we talk about more boring stuff like our families and jobs and so on, since everyone basically aged out of the scene in our early 30s.

I recently made a post about how my mom had been abusive towards me as a kid.

Almost every single person on the email list responded with a similar story of abuse, sometimes of a horrific nature. And almost everyone talked about dealing with trauma and depression their whole lives — and how the rave scene and the drugs they took probably saved them. Several talked about suicide attempts before getting into raves.

I had known these people for almost 15 years and I had never really talked about this except for the random conversation on ecstasy with one or two of them where they or I as sort of worked out our issues with them at an after party or whatever.

I was pretty surprised at how consistent the story was. I know that’s how I felt about the drugs— that the combination of those two (and lsd to a lesser extent) and the community around the music probably saved my life — even though I took a lot of dumb chances and went well beyond the therapeutic info the hedonistic from time to time.

I went from being a lonely, closed up victim of abuse at home and a decade of bullying at school to being outgoing and popular in that scene - even to the point where I learned to DJ and played gigs in front of crowds of 1000+ people.

It helped me not just in the scene but in my personal life and my career. I learned to recognize some of my learned toxic behaviors that pushed people away from me and how to recognize them in other people. I distanced myself from my family and home town friends who had been treating me terribly, and my career took off — even with no degree — and largely because of connections I made in the scene.

I don’t know where I’m going with this, but it seemed transparently obvious at the time that MDMA, LSD and ketamine were near-miraculous substances and deserving of serious scientific study, and it always seemed perverse that the government was doing everything in its power to prevent people from taking them, while at the same time pushing people to take anti depressants and stimulants that were so much less helpful and enlightening.

I haven’t used drugs in nearly a decade and don’t intend to, but I’m glad that researchers are starting to take them seriously.

Re: Ketamine has 'fast-acting benefits' for depression

#79
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

> and the potential that there are long term side effects that have yet to be discovered.

Not for medical which is maybe what you are referring to. But long term (recreational) ketamine use (abuse) is well known. Perhaps down to the method of injection (nasal) or the impurities in illicit ketamine, but there is a lot of information on bladder problems, stomach cramps along with heavy addiction

Re: Ketamine has 'fast-acting benefits' for depression

#80
post #50

If you're an American, every time you read a new article on Ketamine for depression your thought should be "Jeese, healthcare is screwed up". Pharma companies don't benefit from getting Ketamine approved (since it's no longer patent protected), so no one is putting it through FDA for depression. As a result insurance will never cover it (under the current model). The reason this treatment isn't mainstream isn't becau…

> Pharma companies don't benefit from getting Ketamine approved (since it's no longer patent protected), so no one is putting it through FDA for depression. This is incorrect. There are ongoing phase 3 clinical trials for nasally applied esketamine that will lead to FDA approval if succesfully reviewed. These trials are conducted worldwide and are very encouraging. The specific application seems to be patentable. Fir…

> This is incorrect. There are ongoing phase 3 clinical trials for nasally applied esketamine that will lead to FDA approval if succesfully reviewed.

Specifically esketamine, not ketamine, because focusing on this specific isomer was the only way to get a new patent.

What if racemic ketamine performs better than esketamine? We'll never know because they won't test that.

Post reply on HN