First clear evidence cell phone radiation can cause cancer in rats

First clear evidence cell phone radiation can cause cancer in rats
qz.com

If they replicate these particular findings in a preregistered trial, that might move the needle (even better if someone else does).

Unfortunately, if a new preregistered trial does come out showing that this is negative, I doubt it will be as widely disseminated, or undo the association between cell phones and cancer created by this story.

> "The papers found that, in male rats, this exposure increased malignant tumors called schwannomas in the connective tissues that surround nerves in the heart, raised the risk of heart conditions, and led to evidence of DNA damage. Baby rats born to mothers during the trial had lower birth weights. The scientists also found a statistically significant increase in lymphoma (cancer of the lymph nodes) among female mice and heightened rates of liver cancer in the male mice."

What the paper says the results were (https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2018/march/t...):

> "In the 2-year studies, there was significantly lower survival in the shared male sham control group compared to almost all exposed groups, for both modulations. Survival began to decline at a faster rate than in exposed groups after week 75. In the sham control group, 28% of animals survived to study termination, compared to 48% to 68% for exposed groups across both modulations. Lower survival in sham control male rats was largely attributed to higher severity of chronic progressive nephropathy and there was a spectrum of lesions in other organs considered secondary to chronic progressive nephropathy that occurred at higher incidences in male sham controls. Survival in the shared female sham control group was significantly lower than the 6 W/kg CDMA-exposed group; however, it was similar to all other exposure groups, across modulations. At study termination, there was no effect on body weight in male or female rats, and there were no exposure-related clinical observations."

So the Quartz article says cell phone radiation kills rats, and the paper says that rats are less likely to die if they're exposed to cell phone radiation. Then the paper p-hacks its way through a bunch of specific conditions and subtypes of cancer, but really, that won't fool anyone who actually reads the paper and actually understands what they're reading. But it did fool the Quartz author, apparently.

> At the 14-week interim evaluation, there were increased incidences of right ventricular cardiomyopathy in the heart of male rats following exposure to GSM- and CDMA-modulated cell phone RFR compared to sham controls.

And a little further down:

> Following exposure to GSM- or CDMA-modulated cell phone RFR, there were increases in the incidences of malignant schwannoma in the heart of male rats

But there's still one significant increase in cancer in their data, so let's look more closely at that: "A statistically significant increase in the incidence of heart Schwannomas was observed in treated male rats at the highest dose." When it comes to this type of cancer, the control group of 817 rats developed four tumors. But critically, all of those tumors occurred in females; none in males. This apparent sex bias will necessarily exaggerate the impact of any tumors in any of the male experimental populations.

And that's exactly what you see happening. In one female population, 2.2 percent of an experimental group developed this type of tumor, but that was not a statistically significant result. By contrast, in this male population with the significant difference, only 1.5 percent of the animals developed these tumors. A low-dose group of males had the same number of tumors, but the group was larger and so the result slipped below significance.

These numbers suggest that the one statistical effect seen in this study is caused by the unusually low tumor incidence in the control group, rather than a specific effect of cellphone radiation.