The antidepressant effect of sleep deprivation
11–20 of 162 posts
Re: The antidepressant effect of sleep deprivation
#12It sounds like the theory behind this is kicking the circadian rhythm to see if it improves. > Depression is also associated with altered daily rhythms of hormone secretion and body temperature, and the more severe the illness, the greater the degree of disruption. Like the sleep signals, these rhythms are also driven by the body’s circadian system, which itself is driven by a set of interacting proteins, encoded by…
Re: The antidepressant effect of sleep deprivation
#13So the cure for depression is to take hallucinogens like ketamine or deliberately deprive yourself of sleep? It's like making yourself happier by making yourself less sharp. Perhaps, then, one is depressed because one is rational - because there are real, serious problems with life that need to be dealt with, not escaped. The recent "cures" sound almost Huxley-an.
Depression is a thing that happens to you, an ailment that occurs. Sadness about a sad thing is not depression, apathy because things aren't going okay is not depression. They can lead to depression if they go on long enough, but they aren't themselves a mental disorder. They're just emotions.
Depression is a mental disorder. An incorrectly operating subroutine in your brain that's flooding you with emotions that make no sense and shutting down others that you would normally feel given the circumstances.
You stop smiling at puppies, you stop crying for movies, but then you cry because you dropped your fork, and get annoyed that people you love are talking (okay, sometimes that's normal!).
Granted, your line of thinking is why I think some people stay at jobs they hate, stress themselves out with it, and then fall into depression through years of stress and apathy toward their health. But you could also suffer from depression while working a job you love and sleeping on stacks of cash every night.
Re: The antidepressant effect of sleep deprivation
#14So the cure for depression is to take hallucinogens like ketamine or deliberately deprive yourself of sleep? It's like making yourself happier by making yourself less sharp. Perhaps, then, one is depressed because one is rational - because there are real, serious problems with life that need to be dealt with, not escaped. The recent "cures" sound almost Huxley-an.
In the case of ketamine, the improvement might be produced by a metabolic derivative with fewer side-effects than ketamine [1]. And it improves the connectivity of the brain [2] [3], so most likely doesn't make the patient "less sharp".
For what it's worth, exercise can have the same effect [4].
[1] https://arstechnica.com/science/2016/05/understanding-ketami...
[2] https://www.ncbi.nlm.nih.gov/pubmed/25613382
[3] https://www.ted.com/talks/rebecca_brachman_could_a_drug_prev...
Re: The antidepressant effect of sleep deprivation
#15It seems resetting your circadian rhythm can, in some circumstances, have beneficial effect.
I knew someone that referred to doing that as "degaussing".
Re: The antidepressant effect of sleep deprivation
#16So the cure for depression is to take hallucinogens like ketamine or deliberately deprive yourself of sleep? It's like making yourself happier by making yourself less sharp. Perhaps, then, one is depressed because one is rational - because there are real, serious problems with life that need to be dealt with, not escaped. The recent "cures" sound almost Huxley-an.
You can be depressed due to specific problems... and you can be depressed because your brain sucks. The latter is something that's nice to just get rid of, somehow.
Re: The antidepressant effect of sleep deprivation
#17For each of the last seven weeks, I stay awake from Thursday morning until my "regular" bedtime hour Friday evening.
I do this because it actually seems to be an effective way to avoid falling into a hole of anhedonia and "stuck-ness." I am hip to many of the cognitive tricks of depression, and can deal, kind of--I am utterly unable to deal with the physical listlessness and absence of drive that comes with it.
Skipping sleep on a set schedule seems to work for me. At first I didn't think I could keep it up, and I was concerned by potential safety hazards. My concerns are justified, as I am pretty loopy by Friday afternoon, or around the 32 hour mark.
Of all the esoteric treatments for my mood, this is perhaps the only real success except for Yoga (BKS-style Ashtanga).
I have a feeling I might receive some benefit from ascetic practices in general; and will experiment with caloric restriction, e.g. in future months.
I have no idea if I should expect the effects of this practice to remain pronounced, and my experience seems to differ somewhat from that described in the article.
I sure hope I continue to benefit, because I don't respond well to any of the usual methodologies. Also, I don't feel comfortable enough in the onions to do a proper Ketamine trial.
// I don't mean to sound breezy. I only include that last note to emphasize how unendurable my world was becoming.
If this makes sense to you, I feel for you. One foot in front of the other...
The downside: I am totally sober, but I know my executive function is not working very well, and I may very well regret commenting.
edit: some glaring issues with words
Re: The antidepressant effect of sleep deprivation
#18Re: The antidepressant effect of sleep deprivation
#19I used to "play" with my sleeping pattern a lot. I would stay up extremely late sometimes because it's impossible to go to sleep before a bug has been fixed. But being a student I could just sleep in the next day. It had that classic effect which is observed in hackers of drifting "West" and becoming completely out of phase with the Sun's cycle.
I did suffer from depression. It's always difficult to say this, though. How do I know that I really had depression and I wasn't just unhappy? I don't know. But maybe it suffices to say that I had near constant suicidal thoughts at times.
I've since turned my life around and I am no longer depressed. I attribute it to having a much more regimented life which includes regular and sufficient sleep, regular, healthy meals and regular exercise.
So the above quotation suggests that I am "healthy". Presumably as opposed to those that are "unhealthy" and really have depression. But what is the difference really? I have to do this particular thing to avoid depression, and they have to do that particular thing to avoid it? Is it just that my "cure" happens to be the same as everyone else's cure? Or am I missing something here?
Re: The antidepressant effect of sleep deprivation
#20The article talks about "recent studies" without linking to them. The "references" section at the end links to a single peer-reviewed article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447205/) in a journal with an impact factor of less then one (compare https://www.researchgate.net/journal/0379-5284_Saudi_medical... for example).
If it works, why not give some citations in more reputable journals, for example?
Most articles, when searching for depression + sleep deprivation, talk about the correlation between the two, which seems to be pretty well-established. There's little on the possible treatment of depression through sleep deprivation.
I found a meta-analysis on the subject: http://europepmc.org/abstract/med/28937707
"The overall response rate to sleep deprivation was 45% among studies that utilized a randomized control group and 50% among studies that did not. The response to sleep deprivation was not affected significantly by the type of sleep deprivation performed, the nature of the clinical sample, medication status, the definition of response used, or age and gender of the sample.These findings support a significant effect of sleep deprivation and suggest the need for future studies [...]"
I don't have the qualifications to assess this meta analysis; at least it's published in a more popular/reputable journal.