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Brain tissue samples suggest we stop growing new neurons in our early teens

latimes.com

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Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#11

Earlier quoted context omitted.

Theseus Ship of cell replacement?

See The Delphic Boat [0] for a discussion of this in detail. [0]: http://digitalcommons.dartmouth.edu/cgi/viewcontent.cgi?arti...

Wow, thanks for the link. Kind of humbling when you think you've hit on a clever reference and someone's written a book about it =)

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#13
post #2

Unless it happens somewhere other than the hippocampus..

I was wondering as well, is it possible that there’s another part that it happens instead?

Adult neurogenesis has been seen in other species in the olfactory bulb, I don't think this has ever been observed in humans though.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#14
This article has some good insights from other researchers and their different opinions on the study:

https://www.theatlantic.com/science/archive/2018/03/do-adult...

Adult neurogenesis in rats was my thesis focus, so it's interesting that all the rat work we did may or may not translate over to humans.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#15
post #3

I'm gonna wait for the replication, as always. But what about all that exercise-induced BDNF-mediated neurogenesis stuff? Was that only observed in mouse models?

Neurogenesis in the hippocampus and olfactory bulbs is ongoing trough the lifespan. I am presuming this is not about that neurogenesis.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#16
post #3

I'm gonna wait for the replication, as always. But what about all that exercise-induced BDNF-mediated neurogenesis stuff? Was that only observed in mouse models?

Neurogenesis in the hippocampus and olfactory bulbs is ongoing trough the lifespan. I am presuming this is not about that neurogenesis.

Actually, that's exactly what they're claiming to refute:

> A small number of papers had indicated that humans also possessed this capability, specifically in an interior region of the brain known as the hippocampus, which is associated with memory.

> A team from UC San Francisco had hoped to see evidence of this neurogenesis in action.

> Team members examined brain tissue samples collected from 59 human subjects who ranged in age from a 14-week-old fetus to a 77-year-old man. But they couldn't find what they were looking for.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#18

Absolute pitch is something that supposedly can only be learned before the age of 6 but the drug Valproate seems to reopen this window. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848041/

I learned it as a teenager and lost it in my 20s. Like anything I learned it through practice and familiarity. Once I stopped working in music production I slowly lost my absolute pitch too. Similar to the way I used to be able to speak French but now can only string a few words together.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#19
post #16

Earlier quoted context omitted.

Neurogenesis in the hippocampus and olfactory bulbs is ongoing trough the lifespan. I am presuming this is not about that neurogenesis.

Actually, that's exactly what they're claiming to refute: > A small number of papers had indicated that humans also possessed this capability, specifically in an interior region of the brain known as the hippocampus, which is associated with memory. > A team from UC San Francisco had hoped to see evidence of this neurogenesis in action. > Team members examined brain tissue samples collected from 59 human subjects who…

I am floored.

Re: Brain tissue samples suggest we stop growing new neurons in our early teens

#20

Absolute pitch is something that supposedly can only be learned before the age of 6 but the drug Valproate seems to reopen this window. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848041/

I learned it as a teenager and lost it in my 20s. Like anything I learned it through practice and familiarity. Once I stopped working in music production I slowly lost my absolute pitch too. Similar to the way I used to be able to speak French but now can only string a few words together.

Similarly, I took German and French in school, and got quite good grades. However, I've not had much occasion to use either language since then. I did read some German news articles, so that part is sort of OK still.

I've been with my (German) girlfriend for about a year now, and have visited her family in Germany a couple of times. It has really made me realize how much of my ability to put together a sentence in German has simply vanished over the last 15-16 years. I'm boning up using Duolingo now, because I really want to be able to have a full conversation with her (not very English speaking) family.

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