I would need my European/Asian food.....(especially great sushi and some Michelin caliber restaurants), easy beach access, good weather most of the year, and some tech meetups to go to. Probably not for me.
I just want a decent electronic music scene (anything with regular non-house non-edm events) but that alone means i have to stick to pretty big cities :(
Granted, you said decent scene, and I wouldn't necessarily qualify a single "large" event (for the region) a decent scene, but it doesn't mean there has to be nothing.
edit: Also, some of the regional small cities can attract a lot of shows. Boise, ID is particularly good at it, even with a pop < 250k. Boise also has a pretty decent tech drawing, but that's more on the hardware side, I think, Boise is Micron's headquarters. Boise is also a great city to live in. My parents were there for a while when I was in college. Quite a fun city for its size. Ethnic foods are somewhat limited, but you can get very good Mexican and Basque food there (loved the Basque food in particular).