If you would like 10-100x faster performance than Python, but would like to keep the easy-to-read code, give Nim [0] a try. I do all my work in Python, and I've been using Nim in last couple of months - it took me a week or two until I was able to be productive in Nim. Don't expect Python's large ecosystem, nor some Python goodies, but if you're looking for a readable, writable, high-performance post-Python language…
Or just program a module in C or Cython.
You can do that in Nim - it compiles to C.
If you have no previous knowledge of C, with Nim you get C-like speed with Python-like easy to write syntax.