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Cancer ‘vaccine’ eliminates tumors in mice

med.stanford.edu

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Re: Cancer ‘vaccine’ eliminates tumors in mice

#111

Post by randcraw »

yetihehe wrote: post #48
vadimberman wrote: post #31

A layman's question: is it implied to be a universal cure, or for a specific type?

Both. It's targeted by injecting into one tumour, but many different tumours can be targetted. Once targetted, this tumour is eliminated along with all "copies" in body. If you had breast cancer and colon cancer you would need two injections.

Yes, but it's hard to say yet how much different the therapy process might be in humans. The treatment regimen could differ from mice significantly. (Human tumors may be buried a lot farther away from the surface than in a mouse, and thus, harder to dose accurately with a long needle.)

It's also not clear what toxicities were incurred with this therapy (in mice), which is a significant concern for the approval of any drug in humans.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#112

Post by mft_ »

shadowtree wrote: post #72

If they’re at mice this is, at best, 10 years away from getting approved for humans. Immuno-Oncology is the hot new shit, a huge wave of biotech startups is betting everything on it. Celgene bought Juno for 11bn recently, Gilead bought Kite for 12bn. Puts tech startups into perspective :) Tres commas...

1) These drugs are already being tested in humans

2) The pathway from first-in-man to approval can be a lot shorter than 10 years for promising drugs or combinations. Pembrolizumab, for example, took roughly four years: https://en.wikipedia.org/wiki/Pembrolizumab#History

Re: Cancer ‘vaccine’ eliminates tumors in mice

#113

Post by randcraw »

danieltillett wrote: post #47
lwhalen wrote: post #11

Earlier quoted context omitted.

We have cured cancer in mice many times. The trick is getting it formulated for humans in ways that are similarly effective and non-lethal. Put another way, signs of efficacy in mice is necessary, but not sufficient, of a human-applicable treatment.

As far as I know we aren’t able to cure cancer in mice. Sure we can cure them of artificial cancers we give them in the lab, but actually curing spontaneous mouse cancer in outbred mouse populations (i.e. something like human cancer) is not something I have ever seen anyone try, let alone succeed.

The article does mention that they also treated a strain of mice that routinely develops tumors in "all ten breasts" and they responded to the therapy too, but not as fully, requiring multiple treatments and not yielding as high a rate of success.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#114

Post by jdironman »

rossdavidh wrote: post #94
rplnt wrote: post #41

Earlier quoted context omitted.

There's plenty of drugs that are made by multiple companies. It might not make sense for a very specific drug which sees low use, but I think it's viable to produce a drug that might be beneficial to virtually anyone even if you don't have exclusivity.

The issue is who is going to pay for the extensive testing required to get from lab to hospital. That takes years, and lot of organizational skill, and a lot of money. If a drug has gone off-patent, all that is already done, so many companies will be glad to manufacture it. But for new treatments, somebody has to push it through clinical trials, with the (quite substantial) risk that something which looked good in th…

Seems like a legitimate place for our tax dollars to fall in comparison to where they normally do.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#116

Post by skohan »

nautilus12 wrote: post #32

i feel like i see a new 'cure' every week. How is this different aside from the pedigree?

It might seem like noise, but there is progress being made. My cousin's girlfriend takes a pill every day which has basically eliminated her lung cancer for all intents and purposes because it targets the specific mutation which is in the problem in her case.

Relatively new T-Cell therapies "train" the body's own immune system to recognize and delete cancer cells with much fewer negative effects than traditional treatments like radiation or chemotherapy.

Stories like this don't mean an end to cancer, but it's still very good news.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#117

Post by bradleyjg »

mark212 wrote: post #67
jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

My wife and I are about one year ahead of you with the same diagnosis, currently fighting a recurrence. Keep fighting, stay positive. (And yes the science is astounding and rapidly developing.)

My best friend is 8 years and counting with stage III (not sure about the sub-stage) ovarian. Both of you, hang in there!

Re: Cancer ‘vaccine’ eliminates tumors in mice

#118

Post by lr4444lr »

nsxwolf wrote: post #85
jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

A different monoclonal antibody treatment successfully treated my grandfather’s lymphoma 10 years ago. It had spread to occupy large portions of his lungs and this treatment was nothing short of miraculous. We watched in awe as the tumors shrunk away. I hope it works as well for her.

I don't like to pry, but since my father had rare inoperable non-metastatic brain lymphoma and I have genetic concerns, is he still alive? What is his prognosis? How did he tolerate the treatment? (My apologies if it's too personal to discuss.)

Re: Cancer ‘vaccine’ eliminates tumors in mice

#119

Post by oculusthrift »

murukesh_s wrote: post #36

I hope this will work out for humans as well. Wondering if we can have something for diabetes as well, it seems to be affecting a large portion of the population and growing rapidly.

we have a vaccine for that. it’s called diet and exercise.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#120

Post by FiveSquared »

jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

Stay strong!
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