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Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

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Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#191

Turmeric has been used in India since ancient times. There are many references to it in Ayurveda - the Indian/Hindu medical sciences. Ayurveda believes in using food as medicine to non only prevent a large majority of human diseases, but also to cure several of them — all with almost zero side effects. Turmeric is just one such extremely powerful & healthy food item that Western science seems to be playing catch up o…

Ayurvedic medicine is far from infallible. Take this for instance, a selection from a reasonably popular Ayurvedic text (https://www.amazon.in/Bhojan-Chikitsa-1-Ganesh-Narayan-Chauh...) that is aimed at a general audience and purports to explain the health benefits of various common foods (my translation follows):

> कैंसर: कैंसर में पहले तीन दिन रोगी को उपवास कराएं, फिर अंगूर सेवन कराना आरम्भ करें। कभी-कभी एनिमा लगाएं। एक दिन में दो किलो से अधिक अंगूर न खिलाएं। कुछ दिन पश्चात छाछ पीने को दी जा सकती है। अन्य कोई चीज़ खाने को न दें। इससे लाभ धीरे-धीरे महीनों में होता है। इसकी पुल्टिस घावों पर लगा सकते हैं। इस रोग की चिकित्सा में कभी-कभी अंगूर का रस लेने से पेट-दर्द मलद्वार पर जलन होती है। इससे डरना नहीं चाहिए। दर्द कुछ दिनों में ठीक हो जाता है। दर्द होने पर सेक कर सकते हैं।

> Cancer: for cancer, have the patient fast for three days, then begin their intake of grapes. Perform enemas intermittently. Don't feed the patient more than two kilos of grapes in a day. After a few days, buttermilk may be given for drinking. Do not provide anything else to drink. In the next few months, an improvement will slowly be noted. A poultice may be applied to their wounds. In the course of the treatment of this disease, the intake of grape juice will occasionally cause stomachaches and a burning sensation on the anus. This is no cause for concern. The pain will subside in a few days. Compressions may be given to alleviate the pain.

You could argue that such obvious quackery has also been peddled by Western doctors who are trained in the scientific method. That is true, but at least these doctors' manuscripts wouldn't be accepted by any reputable journal. Admittedly I'm not sure how the Ayurvedic medical community organizes itself in India, but I'm willing to bet it doesn't place so much emphasis on the scientific method, and you also imply this in your comment.

A less extreme example of what's found in the book, a remedy for diabetes using bitter gourd juice:

> मधुमेह: रोगी को १५ ग्राम करेले का रस सौ ग्राम पानी में मिलाकर नित्य तीन बार करीब तीन महीने पिलाना चाहिए। खाने में भी करेले की सब्ज़ी लें।

> Diabetes: Have the patient drink 15 grams of bitter gourd juice in 100 grams of water 3 times daily continuously for three months. They should also eat cooked bitter gourd.

I think you'd agree that the remedy above isn't as good a treatment for diabetes as an insulin regimen--the one prescribed, by the way, by Western medicine.

In summary, there's no doubt that traditional systems of medicine like Ayurveda or Chinese traditional medicine have discovered legitimate remedies, but it seems like they generally prescribe a large number of false positive treatments. And if you also believe that the scientific method is the best epistemological apparatus that humans have found so far, then you should be skeptical of these remedies until they have been clinically demonstrated to be effective.

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#192

>Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration My very first question was: Please provide a possible physiological pathway for this. I'm so glad it was answered in the very first sentence. So many of these "Superfood does X" studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skep…

I vaguely remember reading that the physiology of acetaminophen is still not completely understood. I doubt we will be lucky to figure this one out quickly. I also remember reading that the level of dementia in India is much lower than western nations and turmeric was thought to be part of the reason for that.

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#193
I'm surprised no one has mentioned here that there's been research on using Turmeric as an antidepressant. It's known to increase BDNF in the brain, the same protein generated during aerobic exercise. BDNF is one of the reasons exercise is so beneficial for mental health.

"Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF" (https://www.sciencedirect.com/science/article/pii/S016643281...)

"Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes" (http://www.nrcresearchpress.com/doi/10.1139/apnm-2013-0133)

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#195

>Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration My very first question was: Please provide a possible physiological pathway for this. I'm so glad it was answered in the very first sentence. So many of these "Superfood does X" studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skep…

I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…

Obviously you don't understand HN.. everyone here is a "very smart software engineer" and knows far better than a simpleton like you with your decades of medical training and experience.

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#196

Earlier quoted context omitted.

I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…

I am having trouble accepting your argument. Judea Pearl presents [0] the debate over whether smoking causes cancer as an illustration for why correlation is not sufficient. Two plausible, contradictory, models ('smoking causes cancer', 'no it doesn't, something else does') could not be settled by observing correlations. The debate was resolved through the addition of an explanatory mechanism, and a test of the mecha…

This study established causality with double blind test and thee effects size was really big.

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#197

Earlier quoted context omitted.

I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…

Obviously you don't understand HN.. everyone here is a "very smart software engineer" and knows far better than a simpleton like you with your decades of medical training and experience.

There are professional statisticians who believe the same as this HN cult.

http://andrewgelman.com/2017/01/30/no-guru-no-method-no-teac...

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#198

30 total people with 15 on placebo seems like a very small sample size to me but a great study to maybe get funding for a bigger one for sure.

Everyone without statistical training thinks sample sizes are too small, but rest assured these studies are usually planned very deliberately. Power calculations are usually done in advance to determine the necessary sample sizes needed to demonstrate the magnitudes of different hypothesized effects according to a desired confidence level.

http://andrewgelman.com/2017/12/04/80-power-lie/

Re: Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds

#200
post #117

Earlier quoted context omitted.

> 200ml of hot (not boiling) milk If you're lactose intolerant, you can do this with yoghurt with a little water & salt instead. Since this usually happens when I do have a cold, my laziness translates into a coffee cup of yoghurt + water + 1 minute in a microwave to zap all the bacteria out of it.

There is a school of thought that the worst thing to consume in case of a cold is dairy.

I think that's an old wives' tale. There's probably a better article somewhere, but I found this one: http://www.bbc.com/future/story/20170421-should-you-avoid-ic...
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