151–160 of 406 posts
Earlier quoted context omitted.
It also seems to stain chopping boards.
Yes, it can stain skin as well. Actually, you can apply it to the skin (via a recipe) to make it vibrant. This is common practice in India. I usually get turmeric powder (unadulterated) instead of raw.
Only reason I've used the root is when I'm out of ginger. Not perfect substitute, but, meh, kind of okay.
>Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration My very first question was: Please provide a possible physiological pathway for this. I'm so glad it was answered in the very first sentence. So many of these "Superfood does X" studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skep…
I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…
For those commenting on bioavailability, black pepper supposedly makes it more bioavailable: https://examine.com/supplements/curcumin/ It's an interesting result, but they do note that the subpopulation is somewhat self-selected: "Only approximately 15% of the screened volunteers were included in the study, and our recruitment method yielded a sample of motivated, educated, physically healthy subjects concerned about…
Black pepper increases bioavailability of everything by inhibiting your cytochrome p450 enzymes, which increases your vulnerability to toxins.
Also, black pepper inhibits CYP3A4, not 450.
Earlier quoted context omitted.
For all the claims of bioavailability, I was surprised to see that Theracumin(R) doesn't seem to contain piperine[1] or any perines (which are usually in curry powder courtesy of black pepper). The 90mg dosage also seemed low, I have been taking 500mg of 95% extract daily for a couple of years. 1: https://www.ncbi.nlm.nih.gov/pubmed/9619120
Theracurmin's formulation is specifically designed to increase bioavailability without the use of bioperine.
Earlier quoted context omitted.
Black pepper increases bioavailability of everything by inhibiting your cytochrome p450 enzymes, which increases your vulnerability to toxins.
There’s a difference between bioavailability and half life. Metabolic enzyme inhibition increases half life due to decreased hepatic metabolism of certain drugs. Bioavailability is how much of a drug your body absorbs from the initial dose. Also, black pepper inhibits CYP3A4, not 450.
Also, CYP3A4 is one of the p450 enzymes. But after looking it up, piperine does seem to be specific to CYP3A4, which is better than inhibiting p450 in general.
>Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration My very first question was: Please provide a possible physiological pathway for this. I'm so glad it was answered in the very first sentence. So many of these "Superfood does X" studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skep…
I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…
Small study, probably not preregistered (didn't find anything about it in the description). Likely Publication Bias or p-hacking. I'm starting to get interested when it's been independently replicated.
>Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration My very first question was: Please provide a possible physiological pathway for this. I'm so glad it was answered in the very first sentence. So many of these "Superfood does X" studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skep…
I am a neurologist. this is actually the exact opposite of what you should care about, which is "does it work to treat ___" In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness). The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect th…