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Activating circadian clock reduces brain cancer without side effects in mice

cen.acs.org

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Re: Activating circadian clock reduces brain cancer without side effects in mice

#11

Post by Fnoord »

aquadrop wrote: post #9
throwawaycloud wrote: post #6

Earlier quoted context omitted.

I appreciate that, but... When I pass beggars on the street, I've rarely given money to them, even back when I could afford to. It would be a bit hypocritical to do the same thing. Everyone has problems. They don't define me. The main issue is that staying anonymous wouldn't go over well, and I don't want to be known as that guy with ass cancer. A strange thing happened in the dota2 community. Dota 2 is a competitive…

I don't think you should blame yourself about beggars, it's not hypocritical. I don't usually give any money to beggars too, because most probably they are related to some crime groups (someone takes away most of donated money from them) and/or will just spend the money on booze and that's it. On the other hand, I've bought stuff I don't need from beggar-like old women here (babushkas), who just knit socks/hats etc a…

> because most probably they are related to some crime groups (someone takes away most of donated money from them)

Why is that "most probably"?

Btw, you can give other things than money to beggars as well. Bread or a cup of coffee, for example.

Re: Activating circadian clock reduces brain cancer without side effects in mice

#12

Post by throwaway848483 »

olliepop wrote: post #8
throwawaycloud wrote: post #6

Earlier quoted context omitted.

I appreciate that, but... When I pass beggars on the street, I've rarely given money to them, even back when I could afford to. It would be a bit hypocritical to do the same thing. Everyone has problems. They don't define me. The main issue is that staying anonymous wouldn't go over well, and I don't want to be known as that guy with ass cancer. A strange thing happened in the dota2 community. Dota 2 is a competitive…

Very sorry to hear about your situation. FWIW, i had been concealing cancer symptoms for 6 months (denial, was obviously a tumour) when i decided to see a doctor. All tests (physical, bloods, ultrasound) came back negative until I saw a specialist, who confirmed that it was a tumour. Fortunately I was able to visit this extremely expensive expert, because the doctors were not convinced that it was cancerous. Turns ou…

2 > My guess is OP is referring to zeroMQ creator : Pieter Hintjens

Re: Activating circadian clock reduces brain cancer without side effects in mice

#13

Post by toxic_ »

throwawaycloud wrote: post #2

Pretty sure I have cancer. Context: https://news.ycombinator.com/item?id=15889203 FWIW I also have narcolepsy, which took until adulthood to diagnose and had far more devastating effects on my life: https://news.ycombinator.com/item?id=10984478 Didn't want to make this about me, but the coincidence between sleep problems and cancer is interesting enough that it seemed worth chiming in.

I developed narcolepsy in my teens and I can absolutely relate to how you feel. Everyone just thought I was lazy, malingering or, in the case of my general physician, depressed. It took years before I could even see a neurologist, after which an official diagnosis was quickly made.

If you're not already on sodium oxybate (Xyrem), I can't recommend it enough; it's the only thing that puts me in a sound, restorative sleep for more than a few hours.

I'm in the UK where prescriptions for Xyrem are almost impossible to obtain. Fortunately, the precursors for its active ingredient, GHB, are inexpensive and easy to acquire, so I just synthesize it myself. Technically it's illegal, but it would take an especially brave magistrate to convict me for having to overcome deficiencies in the NHS.

Re: Activating circadian clock reduces brain cancer without side effects in mice

#14

Post by theddman »

toxic_ wrote: post #13
throwawaycloud wrote: post #2

Pretty sure I have cancer. Context: https://news.ycombinator.com/item?id=15889203 FWIW I also have narcolepsy, which took until adulthood to diagnose and had far more devastating effects on my life: https://news.ycombinator.com/item?id=10984478 Didn't want to make this about me, but the coincidence between sleep problems and cancer is interesting enough that it seemed worth chiming in.

I developed narcolepsy in my teens and I can absolutely relate to how you feel. Everyone just thought I was lazy, malingering or, in the case of my general physician, depressed. It took years before I could even see a neurologist, after which an official diagnosis was quickly made. If you're not already on sodium oxybate (Xyrem), I can't recommend it enough; it's the only thing that puts me in a sound, restorative sl…

What do you mean synthesize? If you're starting from GHB, then you just titrate up with NaOH to ~neutral?

Re: Activating circadian clock reduces brain cancer without side effects in mice

#15

Post by throwwwwaway9 »

throwawaycloud wrote: post #2

Pretty sure I have cancer. Context: https://news.ycombinator.com/item?id=15889203 FWIW I also have narcolepsy, which took until adulthood to diagnose and had far more devastating effects on my life: https://news.ycombinator.com/item?id=10984478 Didn't want to make this about me, but the coincidence between sleep problems and cancer is interesting enough that it seemed worth chiming in.

Regarding the possible cancer : "The secondary reason is an unhealthy fear of needles and a desire to live without a colostomy bag." you @ https://news.ycombinator.com/item?id=15889203

You can always decide to call it quits the day after, so don't let this stop you. Even if you have it, it may totally disappear. The money issue, I understand.

To be sure, you need a $10+mil net-worth in USA, then whatever happens, you can go to Mayo Clinic and pay cash.

Re: Activating circadian clock reduces brain cancer without side effects in mice

#16

Post by homero »

throwawaycloud wrote: post #2

Pretty sure I have cancer. Context: https://news.ycombinator.com/item?id=15889203 FWIW I also have narcolepsy, which took until adulthood to diagnose and had far more devastating effects on my life: https://news.ycombinator.com/item?id=10984478 Didn't want to make this about me, but the coincidence between sleep problems and cancer is interesting enough that it seemed worth chiming in.

It probably isn't cancer, I have ulcerative colitis which bleeds but you need that colonoscopy. An er will diagnose you, blood in stool is an emergency.

I'm in the same boat as you mentally, I have extreme anxiety and I'm on 4 meds just for that.

Btw, ACA has subsidies, they'll pay a lot of your monthly premium.

Re: Activating circadian clock reduces brain cancer without side effects in mice

#17

Post by ComputerGuru »

theddman wrote: post #14
toxic_ wrote: post #13

Earlier quoted context omitted.

I developed narcolepsy in my teens and I can absolutely relate to how you feel. Everyone just thought I was lazy, malingering or, in the case of my general physician, depressed. It took years before I could even see a neurologist, after which an official diagnosis was quickly made. If you're not already on sodium oxybate (Xyrem), I can't recommend it enough; it's the only thing that puts me in a sound, restorative sl…

What do you mean synthesize? If you're starting from GHB, then you just titrate up with NaOH to ~neutral?

He’s saying GHB is virtually synonymous with Xyrem and GHB isn’t hard to make.

Re: Activating circadian clock reduces brain cancer without side effects in mice

#18

Post by j45 »

aquadrop wrote: post #9
throwawaycloud wrote: post #6

Earlier quoted context omitted.

I appreciate that, but... When I pass beggars on the street, I've rarely given money to them, even back when I could afford to. It would be a bit hypocritical to do the same thing. Everyone has problems. They don't define me. The main issue is that staying anonymous wouldn't go over well, and I don't want to be known as that guy with ass cancer. A strange thing happened in the dota2 community. Dota 2 is a competitive…

I don't think you should blame yourself about beggars, it's not hypocritical. I don't usually give any money to beggars too, because most probably they are related to some crime groups (someone takes away most of donated money from them) and/or will just spend the money on booze and that's it. On the other hand, I've bought stuff I don't need from beggar-like old women here (babushkas), who just knit socks/hats etc a…

I sometimes think about how people with homes drink alcohol for pleasure and sadness.. and wonder how much more they'd drink if they were homeless, especially if they needed to stay warm, etc.

Alcohol isn't my coping mechanism of choice. I'm also not in other people's shoes based on what they might be able to access to get through a few hours or just a day.

Sparked from "..and/or will just spend the money on booze and that's it."

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