> You kind of contradict yourself by saying there is no backlash and then giving a list of supplements to reduce the backlash...
What I am saying is there will certainly be some backlash if you don't do anything to prevent it but you can (or you can not - sure I can't say these advices will help everybody, perhaps some of these may even harm somebody if they have some specific contraindications) effectively prevent about 99% of it. Perhaps my grammar is not perfect but I hope the idea is fairly easy to get.
> What's not proven is those supplements you mention.
Sure, not proven any credible way. Hopefully the researchers will read this thread, take these in consideration and prove or disprove some parts.
> tests on mice
In fact there have been quite enough "testing" on humans though it's neither scientifically clean (no double-blind placebo-controlled trials, no large control groups observed, no measurements etc) nor official enough for obvious reasons. Everything is based on personal experience people share anonymously, but believe me - though not formally credible nor systematic this data is very far from being entirely mythical and useless. It's absolutely worth testing by researchers we are talking about and, well... by unaccredited enthusiasts who are going to to engage in the research on their own perhaps.
> There's also no evidence that supports 'afterglow'
Sure, no evidence, just reportedly-systematic experience of anonymous individuals. Let's just say it may cause this state, not that it necessarily will.
> and magnesium to reduce jaw clenching
Magnesium is not just to reduce jaw clenching, it's also an NDMA antagonist, known to prevent amphetamine-type drugs tolerance. And it is also an important electrolyte that you may loose if you dink, sewat and pee excessively.
> keep your body cooled (but hard to do at parties)
MDMA is, arguably, much more fun and much more safe to take at home together with just the one you love. I especially discourage taking it at parties and especially mixing it with alcohol.
> but doesn't affect the serotonin levels... Taking 5-HTP the days after...
That's why I recommend L-tryptophan. Tough less-famous than 5-HTP (5-Hydroxytryptophan) for a number of reasons, it can be considered a more natural and more safe alternative to 5-HTP. L-tryptophan is the essential amino-acid naturally meant to be consumed regularly (it occurs naturally in many foods and also available in pure form as an over-the-counter supplement) your body uses to produce the amounts of 5-HTP (and then serotonin) it needs from it.
Also St. John's wort is known to upregulate serotonin receptors and increase of serotonin (!!!up to potentially life-threatening levels if combined with other serotonin-boosting substances so never take it together with MDMA, only the day after!!!).
Piracetam and emoxypine are not only antioxidants (in fact I don't even know if piracetam is an antioxidant at all) but nootropics that may improve brain blood flow, oxygen consumption and synaptic transmission, modulate the receptor complexes of the brain membranes by increasing their binding ability, stabilize biomembranes (i.e. membrane structures of blood cells - erythrocytes and thrombocytes during their haemolysis or mechanical injury accompanied by the formation of free radicals), have neuroprotective and anti-inflammatory action, change the monoamine level and increases the dopamine content in the brain etc.
> but again, research is lacking.
That's why it's so great to read about the ladies and gentlemen at the Pineapple Fund going to fund the research and that MAPS is undertaking it. And that's why it's so important to share every potentially valuable idea on the subject with them so they can use it in the research.
There are 2 reasons I am writing this here:
1. I hope this can help people (though I am not sure it will help everybody) to save their health and prevent unpleasant experiences (as far as I've heard overwhelming majority of people who try MDMA experiences rather severe backlashes - this suggests they are doing it wrong and cause damage to their brains).
2. I hope this can provide the researches with ideas to start with when looking for safety measures to be proven scientifically. Surely "making sure that your schedule is clear of obligations the next day" is always a great idea but I think the stuff I've described above (including the previous commentary) should better be used too.