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Beginner's guide to longevity research

ldeming.com

61–70 of 89 posts

Re: Beginner's guide to longevity research

#61
post #60
post #38

Earlier quoted context omitted.

I’ve never actually talked about this online before, but now I’m going to. I used to weigh over 560lbs, and I’ve lost 190 of that, with more going every week. I spent a lot of time on this, tried a lot of diets, tried medication, and ultimately considered surgery. In the end a ferocious commitment to eating less, eating better, and moving around more was what worked, and continues to work. Years ago I went to a medic…

> The active ingredient is not the plan, it is the desire to commit to the plan with all of your being... for years, forever. All of your post is good but this is the most important bit (IMO). The biggest scam the weight loss industry ever pulled on Western civilisation was the redefinition of "diet" from "what you eat" to "a temporary change in what you eat". To maintain a healthy weight you have to monitor your wei…

Thanks very much, and I agree on all counts; it’s really the only advice I can give that I know to be true. You have to want to lose the weight and keep it off, to change profoundly, more than what you’ve been doing for years. The specifics are going to be different for various people, but the commitment over time is the big thing.

Re: Beginner's guide to longevity research

#64

Earlier quoted context omitted.

I'm like you pretty skinny. I started IF and also going to the gym to try and put on weight. I never liked eating breakfast but did it because I thought it was something I had to do. It took me maybe a week or two of not eating breakfast until it felt normal - but now I could never go back. I feel much more in control. Before if I missed breakfast i'd be a mess and my stomach would be making all kinds of noises in me…

I might try this, not because I believe in IF, but just because breakfast is annoying. Does coffee count as breakfast here, though?

Not if it's black.

Re: Beginner's guide to longevity research

#65

That table at the end has a column "Median Lifespan Increase (treated/control)". No, it isn't an increase, it is a ratio. Eg, the first entry, scenescent cell removal %135, is a 35% increase, not a 135% increase.

It would be good to add the base size for the observed effect in each study.

Re: Beginner's guide to longevity research

#67

Earlier quoted context omitted.

I still haven't really figured out how CR is supposed to be sustainable. I am around BMI of 19, and have been as low as 17 (6'2", 133lb). I become extremely unhealthy when I don't eat enough. As far as I know, I can't eat less and maintain the same weight. CR would, for me, send me to the hospital. Is CR just another name for "lose weight"? Is it working towards a goal rather than a lifelong steady state of living?

Caloric restriction is an experimental tool that utilizes “undernutrition without malnutrition.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115619/ A simple interpretation of CR would be: “additional leanness from a normal body weight may add health and life span delaying the process of aging.” Regarding BMI, rule of thumb is 20-ish. CR in the NIA study reduces body weight by 25%, so the NIA CR “man equivalent” wi…

Ok, so really it's just about targeting a leaner body composition, that makes a lot more sense. Thank you.

Re: Beginner's guide to longevity research

#69

I'm a bit surprised at no mention of importance of sleep. Why is that? Or is this because that falls outside of scope of what "longevity research" in this case means?

Seems to me an obvious target. Soundness of sleep seems to decline monotonically from near birth all the way to death

https://twitter.com/clumma/status/764842049199898624

Re: Beginner's guide to longevity research

#70
post #62

Thanks everyone for reading! I'll be around if you have any questions.

I have 3 questions:

1. Did you see the Park et al report on DNA-PK inhibition from earlier this year? https://news.ycombinator.com/item?id=14301878

2. Is anyone working on sleep? https://twitter.com/clumma/status/764842049199898624

3. Have you considered funding low-dose ionizing radiation research? https://www.facebook.com/clumma/activity/10151804061151737

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