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Beginner's guide to longevity research

ldeming.com

51–60 of 89 posts

Re: Beginner's guide to longevity research

#51
post #43

What's the end game here? A future ruled by 400 year old Zuckerbergs and other multi-trillionaires? Much of the progress in society is possible only because previous generations eventually die off. What happens when that's no longer the case?

[deleted]

Re: Beginner's guide to longevity research

#52

Earlier quoted context omitted.

My diet is almost small these days but I'm very curious about IF... Hoping I'll have willpower to do one

Honestly, it takes less willpower to do IF than to not do it :p 1. Wake up 2. Make Breakfast 3. Go on with day vs 1. Wake up 2. Go on with day.

Less work doesn't necessarily mean less willpower. Maybe you don't get very hungry, but some people do and for them that's what makes it take more willpower to fast than not fast.

Another thing to consider is that many people who don't feel like spending the effort to make breakfast will just buy something and eat it. Doesn't take much effort or willpower to stop at Dunkin Donuts or Starbucks on the way to work.

Re: Beginner's guide to longevity research

#53

I'll offer a contrarian view: longevity research, as in the current scope, is about as accurate and useful as Ray Kurzweil's predictions from the 90s. Let's take caloric restriction, for instance, which is all the rage. Trouble is, all of the evidence we have is in mice or lesser animals, and the comparison is animals on caloric restriction against animals being force fed to the point of obesity . Let me repeat that:…

I still haven't really figured out how CR is supposed to be sustainable. I am around BMI of 19, and have been as low as 17 (6'2", 133lb). I become extremely unhealthy when I don't eat enough. As far as I know, I can't eat less and maintain the same weight. CR would, for me, send me to the hospital. Is CR just another name for "lose weight"? Is it working towards a goal rather than a lifelong steady state of living?

Caloric restriction is an experimental tool that utilizes “undernutrition without malnutrition.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115619/

A simple interpretation of CR would be: “additional leanness from a normal body weight may add health and life span delaying the process of aging.”

Regarding BMI, rule of thumb is 20-ish.

CR in the NIA study reduces body weight by 25%, so the NIA CR “man equivalent” will have a BMI of 20.8 (in the lower half of the normal weight category)

Re: Beginner's guide to longevity research

#54

I'll offer a contrarian view: longevity research, as in the current scope, is about as accurate and useful as Ray Kurzweil's predictions from the 90s. Let's take caloric restriction, for instance, which is all the rage. Trouble is, all of the evidence we have is in mice or lesser animals, and the comparison is animals on caloric restriction against animals being force fed to the point of obesity . Let me repeat that:…

While I agree with the general sentiment that CR is probably not very useful for humans, I think you are either misinformed or exaggerating for the sake of generating a response.

Ad-libitum feeding is not force feeding. Noone goes and shoves the food into mice. The food is just available.

Also, CR has extended lives in many species, including dogs (see https://avmajournals.avma.org/doi/abs/10.2460/javma.2002.220...), not just mice.

Re: Beginner's guide to longevity research

#55

I'll offer a contrarian view: longevity research, as in the current scope, is about as accurate and useful as Ray Kurzweil's predictions from the 90s. Let's take caloric restriction, for instance, which is all the rage. Trouble is, all of the evidence we have is in mice or lesser animals, and the comparison is animals on caloric restriction against animals being force fed to the point of obesity . Let me repeat that:…

While I agree with the general sentiment that CR is probably not very useful for humans, I think you are either misinformed or exaggerating for the sake of generating a response. Ad-libitum feeding is not force feeding. Noone goes and shoves the food into mice. The food is just available. Also, CR has extended lives in many species, including dogs (see https://avmajournals.avma.org/doi/abs/10.2460/javma.2002.220... )…

Eh I’ve seen how dogs eat. They will eat until they puke. Mice may be doing the same.

Re: Beginner's guide to longevity research

#56
post #34

Really well written article! And a lot of things I've never heard of. While keto is mentioned, I do think that another diet deserves a mention here: WFPB (whole food plant based). In the book, How Not To Die, Dr Greger bring together the science that underpins this diet. Some one switching to this from a standard american diet can expect to add some healthy years to their lives, based on sci evidence.

Good point. See for example: The Whole Foods Diet: The Lifesaving Plan for Health and Longevity" by John Mackey, Alona Pulde, Matthew Lederman" https://www.goodreads.com/book/show/34837239-the-whole-foods...

Based on research studies cited there, the typical US American stitching from a SAD diet to a whole foods plant-based diet would live about ten years longer, and additionally have a much healthier and happier twenty years or so at the end with much lower likelihood of chronic illness or dementia.

See also: https://bluezones.com/live-longer-better/

For example: https://bluezones.com/exploration/loma-linda-california/ "Today, a community of about 9,000 Adventists in the Loma Linda area are the core of America’s Blue Zone region. They live as much as a decade longer than the rest of us, and much of their longevity can be attributed to vegetarianism and regular exercise. ... Adventists tend to spend time with lots of other Adventists. They find well-being by sharing each other’s values and supporting each other’s habits."

But even as good diet is essential, it is aspects of community and infrastructure that help people keep eating healthy together. Likewise, community and infrastructure can help promote daily exercise. So, ultimately, for most people, longevity is not an individual thing. It is a community thing.

That point on community is also made in the sequel to "Fat, Sick and Nearly Dead": https://en.wikipedia.org/wiki/Fat,_Sick_and_Nearly_Dead and is even made by Dean Ornish in the trailer: http://www.fatsickandnearlydead2.com/

Re: Beginner's guide to longevity research

#57

Earlier quoted context omitted.

I have made many attempts at fasting. I'm skinny as a rake and get very weak without some kind of constant caloric intake. I also get "hangry" and make bad decisions on an empty stomach. Is this just me? Or is this a thing that everyone has and just works through?

I'm like you pretty skinny. I started IF and also going to the gym to try and put on weight. I never liked eating breakfast but did it because I thought it was something I had to do. It took me maybe a week or two of not eating breakfast until it felt normal - but now I could never go back. I feel much more in control. Before if I missed breakfast i'd be a mess and my stomach would be making all kinds of noises in me…

I might try this, not because I believe in IF, but just because breakfast is annoying.

Does coffee count as breakfast here, though?

Re: Beginner's guide to longevity research

#58
post #55

Earlier quoted context omitted.

While I agree with the general sentiment that CR is probably not very useful for humans, I think you are either misinformed or exaggerating for the sake of generating a response. Ad-libitum feeding is not force feeding. Noone goes and shoves the food into mice. The food is just available. Also, CR has extended lives in many species, including dogs (see https://avmajournals.avma.org/doi/abs/10.2460/javma.2002.220... )…

Eh I’ve seen how dogs eat. They will eat until they puke. Mice may be doing the same.

Not sure why you are downvoted, most dogs are always really hungry and different even from an obese human.

Also while comparison to animals can be useful as a starting point it is no proof that it works anything like that in humans.

Re: Beginner's guide to longevity research

#59
post #43

What's the end game here? A future ruled by 400 year old Zuckerbergs and other multi-trillionaires? Much of the progress in society is possible only because previous generations eventually die off. What happens when that's no longer the case?

Hope to God that you're dead by then.

Re: Beginner's guide to longevity research

#60
post #38

Earlier quoted context omitted.

I've lost about half my bodyweight, so I feel like my experience qualifies to me to offer my opinion that Keto's supposed anti-hunger effects are broscience crap. Ephedrine or amphetamines, those work.

I’ve never actually talked about this online before, but now I’m going to. I used to weigh over 560lbs, and I’ve lost 190 of that, with more going every week. I spent a lot of time on this, tried a lot of diets, tried medication, and ultimately considered surgery. In the end a ferocious commitment to eating less, eating better, and moving around more was what worked, and continues to work. Years ago I went to a medic…

> The active ingredient is not the plan, it is the desire to commit to the plan with all of your being... for years, forever.

All of your post is good but this is the most important bit (IMO). The biggest scam the weight loss industry ever pulled on Western civilisation was the redefinition of "diet" from "what you eat" to "a temporary change in what you eat". To maintain a healthy weight you have to monitor your weight, and what you're eating, and adjust the latter in response to the former, forever. It's not a thing with an end. It's how you have to live.

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