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Ibuprofen alters human testicular physiology

pnas.org

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Re: Ibuprofen alters human testicular physiology

#41

Post by Alex3917 »

karlkatzke wrote: post #31
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Ibuprofen doesn’t work as an anti inflammatory until you take at least 2400mg/day.

Have a source on that? When I was in college I had some bad inflammatory issues to the point where I couldn't even walk, but it only took 200mg once or twice a week to completely fix the issue. When I didn't take any at all it would get worse and worse until I couldn't even stand up, but as soon I took it I was completely fine in 20 min or so.

Re: Ibuprofen alters human testicular physiology

#42

Post by inciampati »

kinkrtyavimoodh wrote: post #18
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.

Beautifully written. This thought that I have often half-pondered has now become unified and unforgettable. Thank you.

Re: Ibuprofen alters human testicular physiology

#43

Post by tomcooks »

disconnected wrote: post #27
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

> It might even explain why so many cultures had rites to male adulthood involving extreme pain. Right. And a notable trend among those cultures is that they are all nearly extinct. So much for their fertility. Of course this observation could biased due to my own ignorance. I only remember, like, 3 such cultures, and they were your typical African/Amazonian/Aboriginal tribes that still live in near-neolithic conditi…

The whole body mod movement

Re: Ibuprofen alters human testicular physiology

#44

Post by tomcooks »

3pt14159 wrote: post #30
diryawish wrote: post #6

How sufficient is a sample size of 31 healthy white men?

It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.

Is that 200 a random value or is it the result of a study (with hopefully at least 200 partecipants)

Re: Ibuprofen alters human testicular physiology

#45

Post by ribosometronome »

elchief wrote: post #16
fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

some people can't handle the effect on the stomach. but if you can handle it, it's a good choice. Or marijuana

> marijuana

Unless that makes you anxious.

Re: Ibuprofen alters human testicular physiology

#46

Post by QAPereo »

3pt14159 wrote: post #30
diryawish wrote: post #6

How sufficient is a sample size of 31 healthy white men?

It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.

This is also the cause of rotating advice for decades, eg “eggs are/good/bad/good/bad/good” which is s feedback loop between terrible science, predatory media, and a credulous public.

Re: Ibuprofen alters human testicular physiology

#47

Post by disconnected »

jgust wrote: post #33
disconnected wrote: post #27

Earlier quoted context omitted.

> It might even explain why so many cultures had rites to male adulthood involving extreme pain. Right. And a notable trend among those cultures is that they are all nearly extinct. So much for their fertility. Of course this observation could biased due to my own ignorance. I only remember, like, 3 such cultures, and they were your typical African/Amazonian/Aboriginal tribes that still live in near-neolithic conditi…

See: The NFL

When I think "painful initiation ritual", I think "glove made out of bullet ants" [1] not "organized sporting event in which everyone is wearing armor and hurting someone badly is grounds for stopping the game and rushing him/her to the hospital".

Even if you pick something like Boxing or similar contact sports where the goal is to intentionally hurt your opponent, it is still a far-cry from sticking your hand into a whiting mass of animals that have the most painful bite ever recorded.

[1] https://en.wikipedia.org/wiki/Paraponera_clavata#Initiation_...

Re: Ibuprofen alters human testicular physiology

#48

Post by felipelemos »

fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

I hope that dipyrone be safe.

Re: Ibuprofen alters human testicular physiology

#49

Post by anigbrowl »

Pxtl wrote: post #12

Is it callous of me not to worry about the testosterone levels of professional athletes? Because they seem to generally have enough. I worry more about people with RSI who often depend on overuse of anti-inflammatory meds and aren't demonstrably professionally masculine.

Professional athletes make for a good study population because they tend to keep records of their training/performance/injury status. Also their behavior influences painkiller consumption in the population at large through endorsements or just interviews on their fitness regimen. If you like sports and know your favorite athlete uses a certain class of product to deal with cramps, you're likely to recall that when you're in the drugstore looking to alleviate a similar problem.

Re: Ibuprofen alters human testicular physiology

#50

Post by cookiecaper »

Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Yeah, I have to say "Common drug X has negative side effects after sustained daily exposure to high dosages" is hardly surprising. The study says participants were given 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg.

I'm sure this result is useful for the medical community or men specifically dealing with hypogonadism, but it doesn't seem to have a great deal of relevance to the average consumer who uses ibuprofen for occasional pain relief.

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