Can someone tl;dr this without all the medical jargon?
The last sentence of the abstract does a good job of this: >"Based on the present results, we propose that psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression, enabling patients to reconnect with their emotions." This hypothesis was borne out in the data produced by the experiment. Essentially, they were able to increase empathy in their patien…
Sounds like an alternative might then be loving kindness meditation which is basically a mental workout plan for opening up and feeling kindness to yourself, other people, and human experience in general.
I noticed no effect from microdosing mushrooms (0.5g per day for a few days) but I don't suffer from depression. How long did microdosing take to make a meaningful effect?
I have noticed being more emotional in general (ups and higher, downs are lower). But in my case I would be dosing 0.5g several times a day over the course of three days; knowing that the effect keeps for around 3 hours at +1H. On the other hand at that point of time I did suffer from depression and they would kick me out of the relatively low-peak baseline. I have repeated this a few times.
A low baseline is common in bipolar disorder, too. It was (and to a lesser but unfortunate degree, still is) very commonly misdiagnosed as depression because of this. It reacts quite differently to drugs than depression; many anti-depressants pose a high suicide risk when taken by bipolar individuals. While the overall effect during depressive periods (which can last years) in bipolar seems the same, it seems to have a different underlying cause. Normally you wouldn’t get cycling that fast, but AFAIK, there is even less research so far about how psilocybin affects bipolar disorder. I’m not trying to diagnose anyone... just something to think about for anyone who thinks they might be suffering from depression. I think I was misdiagnosed for many years, leading to decades of ineffective treatments.
Actually no. SSRIs, and their more recent variants, would almost invariably comprise that first and second courses of treatments.
Which is exactly what I'm talking about, against your original claim that "SSRIs are used to treat a different class of depression" sorry if this wasn't clear enough from my post, English is not my first language.
Except still not.
It's not treatment resistant depression until the other stuff hasn't worked. Treatment resistant depression isn't a more exact diagnosis: it's an admission that the previous diagnosis was wrong, and the disease is a different one, with a different etiology and a different form of treatment - both pharmaceutical and from the standpoint of therapy.
Which is exactly what I'm talking about, against your original claim that "SSRIs are used to treat a different class of depression" sorry if this wasn't clear enough from my post, English is not my first language.
Except still not. It's not treatment resistant depression until the other stuff hasn't worked. Treatment resistant depression isn't a more exact diagnosis: it's an admission that the previous diagnosis was wrong, and the disease is a different one, with a different etiology and a different form of treatment - both pharmaceutical and from the standpoint of therapy.
Yes, and the other stuff that didn't work is most of the time SSRI.
Treatment resistant depression is not a class of depression like bipolar or psychotic. It can be any depression that resisted the given treatment - that does not mean that the previous diagnosis was wrong. Exactly like when you diagnose a particular cancer and the the treatment does not work. It's still the same cancer. It has not morphed into something else, it has not jumped to a different type of cell. It just means your treatment options are limited and in this case they didn't work.