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The Big Vitamin D Mistake

ncbi.nlm.nih.gov

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Re: The Big Vitamin D Mistake

#101

Post by skybrian »

yufengg wrote: post #22

tl;dr: we need wayyy more Vitamin D than previously recommended. ~13.3x more. Take supplements to reach 8000 IU/day for adults. existing standards from the NIH: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessiona...

However the article doesn't describe any new research and cites a meta-analysis that has a different conclusion:

"A target range of 25(OH)D of greater than 30 ng/mL could be achieved in most individuals by intake of approximately 1000 IU per day of vitamin D3, which is one quarter the National Academy of Sciences–Institute of Medicine tolerable upper level of intake of 4000 IU per day at ages 9 years and older. Although it is above the National Academy of Sciences–Institute of Medicine–recommended daily allowance of 600 to 800 IU per day, intake of 1000 IU per day has been reported as safe for daily use for almost all adults, according to the recent Endocrine Society clinical guidelines. Still, some authors have expressed concern about the efficacy and absolute safety of doses greater than 1000 IU per day, so caution is reasonable. The Endocrine Society has established a tolerable upper-limit intake of 10 000 IU per day at ages 19 years and older. Doses of vitamin D3 below 10 000 IU per day in adults have not been associated with toxicity, and serum 25(OH)D concentrations less than 200 ng/mL are generally not considered toxic. This leaves a considerable margin of safety for efforts to raise the population concentration of 25(OH)D to 40 ng/mL."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103214/

Re: The Big Vitamin D Mistake

#102

Post by STRiDEX »

noahdesu wrote: post #45

Has anyone had experience ordering blood work (e.g. the vitamin d 25 hydroxy test) without visiting a doctor? I've seen very few references to the set of sites that pop up first online [0, 1, 2, 3] when I've gone looking for reviews in the past. Any suggestions? I'm in CA. [0]: https://www.privatemdlabs.com [1]: http://www.directlabs.com/ [2]: https://www.walkinlab.com/ [3]: https://www.health-tests-direct.com/

I joined one medical in sf and while I did meet with a doctor, you can also do walk-ins for blood tests. It was fast. There is a yearly fee to be a member and they have offices all over CA. https://www.onemedical.com/blog/health-guides/lab-test-guide...

Re: The Big Vitamin D Mistake

#103

Post by skybrian »

theprotocol wrote: post #68

If the recommendations of this study become the guideline, it may validate the other studies suggesting that nearly everyone is deficient in magnesium, which is a co-factor in the Vitamin D / calcium cycle. AFAIK (and correct me if I'm wrong), the vitamin D metabolism requires magnesium, calcium, vitamin K2, and vitamin A. K2 in particular needs special attention, as it's the hardest of the substrates to get.

It's not a study. It's an article that cites other studies.

Re: The Big Vitamin D Mistake

#104

Post by hyperopt »

noahdesu wrote: post #45

Has anyone had experience ordering blood work (e.g. the vitamin d 25 hydroxy test) without visiting a doctor? I've seen very few references to the set of sites that pop up first online [0, 1, 2, 3] when I've gone looking for reviews in the past. Any suggestions? I'm in CA. [0]: https://www.privatemdlabs.com [1]: http://www.directlabs.com/ [2]: https://www.walkinlab.com/ [3]: https://www.health-tests-direct.com/

In CA, Quest Diagnostics requires a doctors note for the tests I've taken. Other providers or other tests may be different.

Re: The Big Vitamin D Mistake

#105

Post by code_duck »

_fq4v wrote: post #23

This supports my lived experience. Found to be incredibly low in vitamin D, and diagnosed with autoimmune thyroiditis. Doctor said to supplement with 2000 IU being the max per day. After seeing no improvement whatsoever in vitamin D levels, and after talking with others with the same issue, I self medicated to 10000 IU / day. Lo and behold my vitamin D levels went back up and my auto-antibodies went back down.

Interesting to hear of a connection between this, type 1 diabetes and autoimmune thyroid disease (Hashimoto's?). I have celiac, also an autoimmune disease, and one of the symptoms is tingly and numb extremities, peripheral neuropathy. I think that's related to the ataxia side of celiac and nerve degeneration from nerves losing their sheathing.

Prior to diagnosis, I learned that the numbness is also a symptom of Vitamin D deficiency and found that taking supplements helped.

Re: The Big Vitamin D Mistake

#106

Post by pauljurczak »

noahdesu wrote: post #45

Has anyone had experience ordering blood work (e.g. the vitamin d 25 hydroxy test) without visiting a doctor? I've seen very few references to the set of sites that pop up first online [0, 1, 2, 3] when I've gone looking for reviews in the past. Any suggestions? I'm in CA. [0]: https://www.privatemdlabs.com [1]: http://www.directlabs.com/ [2]: https://www.walkinlab.com/ [3]: https://www.health-tests-direct.com/

In case you have a health insurance - many plans provide a free yearly preventive care doctor visit, which include basic blood lab work. I took advantage of it many times with different insurance companies.

Re: The Big Vitamin D Mistake

#107

Post by growlix »

Interesting that this stems in part from misinterpretation of confidence intervals. The referenced paper, A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D [0], seems like an excellent example to illustrate how (and how not) to interpret confidence intervals.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210929/#!po=22...

Re: The Big Vitamin D Mistake

#108

Post by nvarsj »

ravar wrote: post #15

Throwing in my two cents. I used to suffer from seasonal mood swings, since taking a daily multivitamin this has been the best winter of my life.

Call me skeptical, but I severely doubt multivitamins can help with depression of any kind. Maybe placebo. TFA is about mortality.

Re: The Big Vitamin D Mistake

#109

Post by guilty001 »

andy_ppp wrote: post #89

If you intend to take vitamin d I read in various places you should also take magnesium and probably vitamin k as well. And less calcium. Everything is interconnected. https://www.precisionnutrition.com/stop-vitamin-d

I recently started taking 3000mg of magnesium per day as magnesium chelate. The bottle recommends three capsules per day for muscle spasms / cramps.

Historically, I have a couple of basic assault charges, an assault with sexual intent charge, I was charged with two counts of trafficking a controlled drug (later dropped).

Shortly after I commenced taking six capsules a day I started feeling a lot less psychotic.

Re: The Big Vitamin D Mistake

#110

Post by ejstronge »

rmm wrote: post #97

I have been taking 5000IU Vitamin D for the past 7 years, with a little more over the winter months. It's stupidly cheap, I get 360 5000IU capsules for $13, so it has cost me less than $100 over that period. Anecdotally, it was a game changer for me personally. I got less sick during the winter, and my overall wellbeing improved greatly. A word of advice, increase Vitamin K intake aswell. Vitamin D helps calcium abso…

I haven't heard this about vitamin K before - please correct me if I'm wrong, but I don't think we know how the mechanism through which vitamin K reduces skeletal fractures.
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