This is probably your best bet if you're just going to build a nice CRUD frontend for a business app, possibly with an API (via DRF). I am doing this right now on a project as it's the shortest path to a win. The API however is written in Java 8 / vertx.
Also APIStar from the creator of DRF is something to keep an eye on. It has Django integrations and I believe is async.
If it were me, I'd probably use something else before I tried to squeeze that much performance out of Python at this point to though. I hope library support catches up and it becomes more convenient, but I don't think a predominantly synchronous ecosystem has really successfully transitioned to async before.