As someone with "journalistic" (but fairly in-depth) knowledge about these topics, my guess is that something like a proof-assistant will have to be paired up with some kind of logic programming system (like Prolog, or a kanren-derived system or something).
I guess then the problem of combinatorial explosion in logic search translates directly to the combinatorial explosion of proof-steps in a proof assistant. Hence my mention of partially-automated (more doable than fully-automated).
Probably some kind of a "database of facts" would also be involved, making it an expert system (reminds me of metamath [1]).
Is it fair to say, partially-automated theorem proving is a fairly advanced version (and not without added complexity) of a proof-assistant, and will help ease some of the grunt work involved in using a proof-assistant by hand?