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Ketamine lifts rodents' mood only if administered by male researchers

nature.com

211–220 of 258 posts

Re: Ketamine lifts rodents' mood only if administered by male researchers

#211

Earlier quoted context omitted.

My personal motto is: Don't be evil. Does that help? ;)

Google has the same motto, and we can see how that's going...

It’s Alphabet now, they don’t have that motto ;)

Re: Ketamine lifts rodents' mood only if administered by male researchers

#212
post #39

Earlier quoted context omitted.

Hardly new. Feynman was criticizing psych research for this sort of thing - inadequate controls - half a century ago in his talk on Cargo Cult Science. http://calteches.library.caltech.edu/51/2/CargoCult.htm

And what happens when you have more variables than you can control? It's naive to think all of them can be controlled, even in simple animals as mice

The problem isn’t having variables you can’t control. The problem is not recognizing these variables, or recognizing them and being too lazy to control for them, and then drawing unwarranted, overly broad hypotheses.

There’s a reason psych has a bigger reproducibility problem than any other field.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#213

Earlier quoted context omitted.

I wonder how practical it would be to automate all the rodent handling/experimenting? Because that seems like it'd be the only way to properly remove such unaccountable influences, like people smelling of cat/giving off different smells and thus influencing the reactions of the animals. Couldn't it also be possible that rodents reacting like that is the result of established practices? I.e.: Rodents get only handled…

Then you would have to deal with the effect of subjecting the mice to such a degree of control, precision of action, predictability of environment, and other factors. As was found with the 'Rat Park' experiments in the 70s, experiments on rats in cages are not informative about the behavior of rats not in cages. It is tremendously difficult to study systems as complex as living animals, and we ignore "unimportant" fa…

Rat Park can only sometimes be replicated:

https://www.ncbi.nlm.nih.gov/pubmed/9148292?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/2616610

https://www.ncbi.nlm.nih.gov/pubmed/3696469

https://www.ncbi.nlm.nih.gov/pubmed/18463628

SSC wrote an article about it:

http://slatestarcodex.com/2017/10/25/against-rat-park/

Re: Ketamine lifts rodents' mood only if administered by male researchers

#214
post #190

Earlier quoted context omitted.

Next you're going explain to me that you're not a "homophobe" because you're not literally "afraid" of homosexuals, you just hate them without fearing them. That's not the way language works, and I've heard all of your arguments before. You have nothing to contribute to the conversation.

All of you: please stop this now.

Would you please un-kill this comment?

https://news.ycombinator.com/item?id=15753759

Re: Ketamine lifts rodents' mood only if administered by male researchers

#215
post #144

Why does the article mention ketamine as a club drug? It's a terrible drug for clubs if anything.

Strongly disagree. Speed and Ketamine in combination is probably the greatest time you'll ever have.

I thought you're not supposed to mix uppers and downers..

Re: Ketamine lifts rodents' mood only if administered by male researchers

#216

Earlier quoted context omitted.

Because, in the extreme, accuracy without precision doesn't tell you a damn thing.

Just like precision without accuracy, but if you get accuracy you know you have a problem, but with only precision you are hopelessly misled. If it was a strict trade-off, I would agree that the answer was somewhere on the middle. But it isn't. Most of the things that give you precision will also give you accuracy. The few things that let you exchange one for the other look too much like cheating, and seem to always…

> Most of the things that give you precision will also give you accuracy.

This is absolutely false - digital clocks are a common example. Precise to the second (or millisecond, or more!) but only as accurate as their setting.

Calculations also give precision without accuracy, like my package of tortilla chips - 13oz (368.5g) They took a measurement or specification precise to the ounce, multiplied by 28.3495, and got 368.5.

Accuracy and precision are independent variables, and the utility of either is usually limited to the order of magnitude of the other. With either "accurate to the second with a precision of milliseconds", or "accurate to the millisecond with precision to the second", you should only report a measurement to the second (or possibly a more precise measurement with an error range).

Re: Ketamine lifts rodents' mood only if administered by male researchers

#217
post #160
post #75

Someone I know used to have to get a blood test every week. One of the regular testers used to hurt him, the other didn't. I'm sure it affected to the stress of the visits which operator was waiting for him. With a small sample of people doing the injecting it's hard to eliminate the effect of operator technique.

So, didn't read the article then? They accounted for that in multiple ways.

No need for the snark, I saw the steps they took to account for that but the fact is that they still had a small pool of human operators.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#218

Earlier quoted context omitted.

Is that intellectually honest, to hide from the truth you know about your food?

It's not, I feel the same way, but it's hard to be intellectually honest. I will be a vegetarian soon I think, it's been getting harder and harder to manage the dissonance since I got a dog.

If it helps, becoming vegetarian simply helps contribute to more human over-population.

Any efficiency gleaned in food production is simply eaten up with billions of new mouths to feed within decades.

I'd prefer an "inefficiently" managed planet with 6B people, versus a "very efficiently" managed planet with 20B vegetarians.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#219

Earlier quoted context omitted.

Accuracy or precision. Pick one?

>>Accuracy or precision Do they have different meaning to you? They are the same thing unless there is some scientific meaning that makes them different of which I'm not aware. i.e. Theory in Science means a different thing than what it means to a layman person.

After your watch battery dies, when you change the battery in your watch, it continues to have a 1 second precision.

But it's inaccurate by many hours because you haven't set it yet.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#220
post #144

Earlier quoted context omitted.

Strongly disagree. Speed and Ketamine in combination is probably the greatest time you'll ever have.

I thought you're not supposed to mix uppers and downers..

You are not supposed to mix uppers and downers.

This is because it increases the danger of drug use and could cause death. But no one has ever said not to mix uppers and downers because it wasn't fun.

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