Live data from Hacker News

Ketamine lifts rodents' mood only if administered by male researchers

nature.com

21–30 of 258 posts

Re: Ketamine lifts rodents' mood only if administered by male researchers

#21
post #20

This reminds me of Feynman's story of the researcher who eliminated possible variables in rat experiments one by one, to find a surprising result (EDIT: To find that rats didn't need smell, spatial relationships, taste, or vision to find the cheese - the sound of the floor was enough) https://www.realclearscience.com/blog/2014/02/the_rat_experi...

Your comment is click bait.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#22
post #3

Before anyone who didn't actually read the link goes off at it - this is a peer reviewed, repeated study - mice react to drugs differently depending on the sex of the researcher, don't in a fume hood, do always in a fume hood with a human male's t-shirt. It potentially plays havoc with ALL past experiments with rodents ...

In college we used to joke that animal behavior should be called animal misbehavior. We literally had one member of our lab group that could work with the mice and get sensible results. Neither of the guys could get any data that made sense, one of the women owned a cat and none of the results she had made any sense, and the fourth person (a woman) had no problem. I'm not sure if anybody suspected that rats reacted d…

Were rats as sensitive as mice?

Re: Ketamine lifts rodents' mood only if administered by male researchers

#23
post #21
post #20

This reminds me of Feynman's story of the researcher who eliminated possible variables in rat experiments one by one, to find a surprising result (EDIT: To find that rats didn't need smell, spatial relationships, taste, or vision to find the cheese - the sound of the floor was enough) https://www.realclearscience.com/blog/2014/02/the_rat_experi...

Your comment is click bait.

Edited

Re: Ketamine lifts rodents' mood only if administered by male researchers

#24
post #20

This reminds me of Feynman's story of the researcher who eliminated possible variables in rat experiments one by one, to find a surprising result (EDIT: To find that rats didn't need smell, spatial relationships, taste, or vision to find the cheese - the sound of the floor was enough) https://www.realclearscience.com/blog/2014/02/the_rat_experi...

TLDR: Long story with a moral of document your steps, and read others documentation lest you fall into the same traps they did.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#25

Earlier quoted context omitted.

You're an ass. Comments like this make me hate people. Why does it even matter what their sexuality is? And why does that group of people need a special name

It's not his first transphobic remark. Not only does he call trans people "traps", but he also objects to using proper pronouns because "I don't like my speech being dictated". It's easy to guess what he's obsessed with and ashamed about, and it's not about his lack of ability to treat people with respect. https://news.ycombinator.com/item?id=15242499 And FYI, in case you're a nice enough person to have missed the re…

Sheesh, when did that start having alt-right connotations?

It's a question anyone remotely into contemporary anime/manga would ponder.

Re: Ketamine lifts rodents' mood only if administered by male researchers

#27
post #18

It's interesting to think about what this could mean for people. We use these mice because they often are convenient models for humans. Are our moods are just as affected by combinations of lots of little things like these - smells, hormones, chemicals in the cleaners, hair products etc. On the scary side imagine being able to use this for evil. Spray something like this on your product to manipulate people's hormona…

Love Potion No. 9?

Re: Ketamine lifts rodents' mood only if administered by male researchers

#28
post #18

It's interesting to think about what this could mean for people. We use these mice because they often are convenient models for humans. Are our moods are just as affected by combinations of lots of little things like these - smells, hormones, chemicals in the cleaners, hair products etc. On the scary side imagine being able to use this for evil. Spray something like this on your product to manipulate people's hormona…

Love Potion No. 9?

[deleted]

Re: Ketamine lifts rodents' mood only if administered by male researchers

#29
post #20

This reminds me of Feynman's story of the researcher who eliminated possible variables in rat experiments one by one, to find a surprising result (EDIT: To find that rats didn't need smell, spatial relationships, taste, or vision to find the cheese - the sound of the floor was enough) https://www.realclearscience.com/blog/2014/02/the_rat_experi...

I never did manage to trace Feynman's story back to a source, but nevertheless, also something Derek Lowe repeatedly covers for biology/chemistry on "In the Pipeline": a lot of the 'cell lines' or 'reagents' used in lab work turn out to just not be what they're supposed to be, either because they never were or they degraded into something else in storage or something. So to give a recent paper he blogged, there's something like 30k papers using "immune system cells" which are actually just HeLas; presumably the cell lines in question got contaminated or swapped somewhere along the way, but that raises the question of what any of those papers mean...

And of course there are similar issues with mice. You have all the different strains which are genetically different, but they'll also be genetically changing over time through drift & selection & mutations, so your Wistar-XXX may not be the Wistar-XXX from 50 years ago. Or mice chow - sure, the label may say it's the same but when was the last time you checked? (Think about that paper about how all sorts of lab animals, supposedly fed constant diets and under constant controlled environments, keep getting fatter over the past century. Something is changing; what? Genetics? Food composition? Micronutrients? Lab infections? Microbiomes? Measurement tools themselves?)

Re: Ketamine lifts rodents' mood only if administered by male researchers

#30
post #10

What if a trans man administers the Ketamine?

The first sentence of the article explains this:

>> "Mouse experiments with the popular club drug ketamine may be skewed by the sex of the researcher performing them, a study suggests."

A persons gender identity disorder is psychological and as they're still biologically female I doubt it would matter.

Post reply on HN