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Why I’m Digging Deep Into Alzheimer’s

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Re: Why I’m Digging Deep Into Alzheimer’s

#91

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

Former Alzheimer's researcher here.

I've never heard of this before. Some cursory googling only turns up a sole author publication by Alan MacDonald in Medical Hypotheses and a few news pieces by dodgy organizations like the Spirochaetal Alzheimer's Assocation.

Despite what a lot of people learn in undergrad psych classes, the evidence linking amyloid beta and tau to AD is quite good and getting stronger with every new molecular paper that comes out.

BTW, there doesn't seem to be a correlation between Lyme disease incidence and AD https://www.ncbi.nlm.nih.gov/pubmed/24840565

Re: Why I’m Digging Deep Into Alzheimer’s

#92
post #77

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

Re Gates; he and his staff identify Subject Matter Experts (SME) for the topics he’s interested in. As you can imagine he has a good network. SMEs are always looking for funding, so he’ll use one of his funding vehicles to invite the SME to apply for funding or meet with the organization. By the time you meet with Bill Gates he would have read your most recent papers and competing theories and will be prepared to cha…

SME seems be "subject matter expert".

Re: Why I’m Digging Deep Into Alzheimer’s

#93

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

Former Alzheimer's researcher here. I've never heard of this before. Some cursory googling only turns up a sole author publication by Alan MacDonald in Medical Hypotheses and a few news pieces by dodgy organizations like the Spirochaetal Alzheimer's Assocation. Despite what a lot of people learn in undergrad psych classes, the evidence linking amyloid beta and tau to AD is quite good and getting stronger with every n…

> the evidence linking amyloid beta and tau to AD is quite good and getting stronger with every new molecular paper that comes out.

Sure, but what causes the amyloid beta? Why wouldn't a long-standing syphilis-like bacterial infection in the CNS cause that sort of protein buildup?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399390/

It's a little shocking to see a "former Alzeheimer's researcher" presume that tau buildup and bacterial infections are mutually exclusive..

That's like saying heart disease can't be caused by arterial scarring because it's caused by plaque buildup.

Re: Why I’m Digging Deep Into Alzheimer’s

#94

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

Former Alzheimer's researcher here. I've never heard of this before. Some cursory googling only turns up a sole author publication by Alan MacDonald in Medical Hypotheses and a few news pieces by dodgy organizations like the Spirochaetal Alzheimer's Assocation. Despite what a lot of people learn in undergrad psych classes, the evidence linking amyloid beta and tau to AD is quite good and getting stronger with every n…

> "evidence linking amyloid beta and tau to AD is quite good"

About 100 discontinued clinical trials targeting amyloid beta disagree with you there, https://www.nature.com/articles/nrd.2017.194

Re: Why I’m Digging Deep Into Alzheimer’s

#95

Cynical answer: "because I'm getting old" :) Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.

Reading between the lines, it's probably more like "because my parents are getting old." If you weren't paying attention before, you will then.

Re: Why I’m Digging Deep Into Alzheimer’s

#96

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

But isn’t Lyme disease just in the eastern us? How would 70% of worldwide alz sufferers acquire it?

Lyme disease is just one of a major class of bacterial infections. Syphilis is another. And there are several others...

https://en.wikipedia.org/wiki/Spirochaete

They aren't just limited to the Eastern US.

Re: Why I’m Digging Deep Into Alzheimer’s

#97
post #81

Earlier quoted context omitted.

But isn’t Lyme disease just in the eastern us? How would 70% of worldwide alz sufferers acquire it?

Good question! That’s why we need research. We don’t know if they have a common cause or just a common mechanism of action. They very well could be the same disease; Lyme Disease is not well understood and has been implicated in all sorts of neurological diseases such as Multiple Sclerosis and Alzheimer’s. But the link isn’t quite obvious enough and the potential treatments, which rules out government money; and aren…

What about this town in South America that has the highest concentration of Alzheimers in the world? The genetic mutation E280A seems to guarantee you get early onset Alzheimers ( at least I think it's 100% , couldn't find any info on what percentage with the mutation get it )

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019728/

https://www.newscientist.com/article/dn28514-conquistador-br...

Re: Why I’m Digging Deep Into Alzheimer’s

#99
post #77

The documentary "Under our Skin" details Alan MacDonald's breakthrough research on how Lyme disease causes Alzheimers. The 4 minute trailer is worth a watch[1], but basically Lyme disease is found in 7 or 10 brains of Alzheimers patients (small sample set). The Lyme disease spirochete literally drills countless pathways in the brain and that causes slow dementia. That spirochete also creates a biofilm which makes it…

Re Gates; he and his staff identify Subject Matter Experts (SME) for the topics he’s interested in. As you can imagine he has a good network. SMEs are always looking for funding, so he’ll use one of his funding vehicles to invite the SME to apply for funding or meet with the organization. By the time you meet with Bill Gates he would have read your most recent papers and competing theories and will be prepared to cha…

Did you watch him question someone who was an expert in a subject that you were also an expert in?

Re: Why I’m Digging Deep Into Alzheimer’s

#100
post #19
post #13

Earlier quoted context omitted.

Thanks! I'd love to have a browser extension which automatically augments shitty websites with community-sourced javascript snippets. E.g. you'd visit idk Forbes.com, and saw that the site is unusable b/c of some shitty undismissable paywall overlay. You "fix" the issue with a few lines of JS, and then upload it via the extension. After going through some kind of vetting/review, the extension will automatically fetch…

Grease Monkey?

Does GreaseMonkey suggests you scripts based on the current site you're visiting?
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