There's the freedom/privacy argument, but I guess this is debatable depending on if you view computer files as an extension of your ideas/knowledge, or an extension of your physical possessions.
Someone brought up the entire "risk of overreach and abuse" argument.
There's also the likelihood of any tools the government has being leaked and used by bad actors (as we have seen too much recently).
Oh, and the "it's technologically impossible" argument, which should be the only one you need -- but they refuse to hear that. (Are there some supposed experts who are telling the DOJ this can be done?)