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As epidemic rages, ER study finds opioids no better than Advil and Tylenol

arstechnica.com

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Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#111

Post by strictnein »

lovich wrote: post #100
strictnein wrote: post #45

Earlier quoted context omitted.

Your view looking into the US may be a little flawed, to be honest. Opioids are also regulated in the US. No one gets them for headaches. Doctors recommend Tylenol and Advil for most aches and pain. The times when my wife and I have received Opioids: broken ankles, back injuries from weight lifting, and after c-sections. I didn't receive them when I broke my collarbones (I've broken both, on separate occasions). > I…

I get fiorecet for migraines after the doctor tried me out on a few other preventative medications which either didn't work or had side effects like making me as sleepy as taking two Benadryl. There as needed and I can go months between refilling the script sometimes but it's still for headaches

I mean, I get migraines too, and they're completely debilitating, but I would personally just classifiy them as something very different than a headache. Undersells just how horrible they can be.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#112

Post by Schizotypy »

Retric wrote: post #90
chucky_z wrote: post #85

Earlier quoted context omitted.

Yep! I tried edibles, joints, and vape pens from 3 different dispensaries in the bay area. The edibles and "free" joint I got from Airfield Supply Co. were the ones that effected me the least negatively.

Interesting, thanks for the heads up. Though, dosage may be the issue even being around smokers can be considered a low dose.

This was my thought as well, dose is most likely the issue. A non tolerant patient will respond to under 10mg thc

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#114

Post by Schizotypy »

katastic wrote: post #95
vrtx0 wrote: post #66

The title of this link is frustrating and misleading. The article clarifies a bit, but I take issue with Ars linking to the specific study with text stating the methodology is the gold standard. That doesn’t mean the conclusion will hold up to scrutiny, or that “extremity pain” is a meaningful dimension. The type of injury (eg. compound fractures, sprains, etc.) could be more meaningful than where the injury is. Ther…

I was about ready to chime in the same thing. I've been on opiods for six years (not by simple choice). I'm also on a literal 15 other medicines. I take around 30+ pills a day I've had multiple back surguries. I've got on average 3 doctor visits a month (those co-pays add up fast!)... for six years. And this all started in my prime... at 25 years old where I went from starting a Ph.D program... to fighting with every…

There are medications being developed for conditions like yours. Nav blockers that work only on specifically nociceptor circuits. I have high hope for targeted compounds like this, it would improve the lives of millions.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#115

Post by ianai »

mturmon wrote: post #93
GordonS wrote: post #89

Earlier quoted context omitted.

I was about to say the same thing - sumatriptan works amazingly well for my migraines. I'm in the UK though, and I seem to recall someone on HN saying it was very expensive in the US.

It might have once been expensive ("Imitrex" (R)(TM)) but there is a generic now. I understand there are also non-pill delivery systems, like nasal or patches, and other permutations that may still be under patent. The pills seem to work for me.

Triptans work for me as well, but they’re too hard on my body. It’s aftually pretty scary how they work.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#116

Post by curun1r »

chucky_z wrote: post #60
testvox wrote: post #48

Earlier quoted context omitted.

Cannabis works pretty well and has minimal side effects, at least compared to those you describe.

Cannabis has pretty awful side-effects for me. It gives me absolutely incredible nausea, to the point where I've tried it ~10 times in varying doses, thinking my dosage was an issue, and out of those I was violently ill 4 of the times. The other 6 times were simply unenjoyable. It doesn't just go away like alcohol either. If I drink too much and throw up, I feel better within a few minutes. For cannabis I remain high…

A lot of people who take cannabis for pain or anxiety take CBD [1] rather than the raw THC-containing plant. There's almost no associated high, so it sounds like you haven't tried it. The abuse of medical marijuana laws to circumvent prohibitions on recreational use has confused the issue, but people shouldn't equate the substances that get consumed recreationally with the much more processed and specific substances that get used medicinally.

Sorry to pick on you, but people should realize that if all they want to do is try cannabis for pain management, they shouldn't let a dislike for the recreational effects deter them because the two can absolutely be separated.

FWIW, I manage my pain with meditation techniques and it's the only form of pain management that I recommend whole-heartedly, so I'm not recommending anyone try CBD. But I know people who take CBD for pain and I think people should, at least, understand how cannabis is used medicinally before saying negative things about it.

[1] https://en.wikipedia.org/wiki/Cannabidiol

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#117

Post by gebeeson »

stefantheard wrote: post #75
blacksmith_tb wrote: post #72

Earlier quoted context omitted.

True for high-THC strains, but not high-CBD / low-THC ones. And of course opioids also famously affect perception: "do not operate heavy machinery" etc.

I have heard that CBD is extremely great as a natural anti inflammatory however the strains that get recommended are so absurdly expensive. On the order of 30ml for 150$ for charlottes web for example. Is it actually worth it? How long does that 30ml bottle last for 150$?

The bottle lasts approx 2 weeks with 'correct dosage'. And that price is the higher end product. I am familiar with the mid-range product which I used for 1.5 months (due to pain) and discontinued it because I honestly couldn't really tell the difference.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#118

Post by tree_of_item »

baldfat wrote: post #96
chucky_z wrote: post #60

Earlier quoted context omitted.

Cannabis has pretty awful side-effects for me. It gives me absolutely incredible nausea, to the point where I've tried it ~10 times in varying doses, thinking my dosage was an issue, and out of those I was violently ill 4 of the times. The other 6 times were simply unenjoyable. It doesn't just go away like alcohol either. If I drink too much and throw up, I feel better within a few minutes. For cannabis I remain high…

I never touched the stuff, but I would end up having to take my friend to the ER. For some reason at different times it would cause an allergic reaction and he would act like he was in septic shock and have dementia. Doctors and I were convinced he was not telling the truth or his stuff was laced. Ended up that he was telling the truth and was clean other than pot. Sad thing was he would keep using pot which ended up…

Cannabis enhances my emotions. I'm normally pretty flat emotionally and cannabis is one of the only things that changes that. I'm not sure what you mean by sedation here.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#119

Post by stefantheard »

gebeeson wrote: post #117
stefantheard wrote: post #75

Earlier quoted context omitted.

I have heard that CBD is extremely great as a natural anti inflammatory however the strains that get recommended are so absurdly expensive. On the order of 30ml for 150$ for charlottes web for example. Is it actually worth it? How long does that 30ml bottle last for 150$?

The bottle lasts approx 2 weeks with 'correct dosage'. And that price is the higher end product. I am familiar with the mid-range product which I used for 1.5 months (due to pain) and discontinued it because I honestly couldn't really tell the difference.

Yeah this is quite disheartening to hear. 300$ a month for something that some people can't even tell the difference with. I don't want to spend 150$ for 30ml of snake oil haha.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#120

Post by evincarofautumn »

Schizotypy wrote: post #112
Retric wrote: post #90

Earlier quoted context omitted.

Interesting, thanks for the heads up. Though, dosage may be the issue even being around smokers can be considered a low dose.

This was my thought as well, dose is most likely the issue. A non tolerant patient will respond to under 10mg thc

“Respond” is an understatement. 10mg THC, with no CBD, represents a typical edible from a dispensary, but as a small person with low tolerance and a fast metabolism, I’ve found that amount of THC by itself ends with me fearfully holding onto the Earth for dear life for a couple hours.

On the bright side, at dispensaries you can know precisely what you’re getting, so at least I can say “this weed will pleasantly reduce my anxiety and pain, that weed will blast me unwillingly into space” which is an option I never had before.

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