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How Ketogenic Diets Curb Inflammation in the Brain

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Re: How Ketogenic Diets Curb Inflammation in the Brain

#11
https://en.wikipedia.org/wiki/Ketogenic_diet

"The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. [...] Almost half of children, and young people, with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet."

doesn't sound like just a fad.

Re: How Ketogenic Diets Curb Inflammation in the Brain

#12
post #11

https://en.wikipedia.org/wiki/Ketogenic_diet "The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. [...] Almost half of children, and young people, with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing…

Definitely not a fad per se. They way it is packaged (Keto) and delivered to the masses makes it seem fad-ish as all quickly ramped-up-to-make-money deals tend to be. I've used keto myself several times though only as short-term diet change. I myself never fully seemed to recover from the Keto-flu even after months of eating strict keto. Adding back natural complex carbs helped me immensely in that regard.

Re: How Ketogenic Diets Curb Inflammation in the Brain

#13
post #11

https://en.wikipedia.org/wiki/Ketogenic_diet "The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. [...] Almost half of children, and young people, with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing…

Definitely not a fad per se. They way it is packaged (Keto) and delivered to the masses makes it seem fad-ish as all quickly ramped-up-to-make-money deals tend to be. I've used keto myself several times though only as short-term diet change. I myself never fully seemed to recover from the Keto-flu even after months of eating strict keto. Adding back natural complex carbs helped me immensely in that regard.

Did you intentionally up your salt intake? Apparently this is important for energy on keto for some reason.

Re: How Ketogenic Diets Curb Inflammation in the Brain

#14
post #3
post #2

The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…

Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.

Modified keto where a higher amount of protein is permitted is much easier to stick to (i.e. 30% protein).. to stay within 0.5-1.5 mmol/L BHB

Re: How Ketogenic Diets Curb Inflammation in the Brain

#15
post #11

https://en.wikipedia.org/wiki/Ketogenic_diet "The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. [...] Almost half of children, and young people, with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing…

Definitely not a fad per se. They way it is packaged (Keto) and delivered to the masses makes it seem fad-ish as all quickly ramped-up-to-make-money deals tend to be. I've used keto myself several times though only as short-term diet change. I myself never fully seemed to recover from the Keto-flu even after months of eating strict keto. Adding back natural complex carbs helped me immensely in that regard.

As trevyn says, you need to make sure you get enough sodium. Ketogenic diet accelerates excretion of sodium ("natriuresis of fasting"). Look up Steve Phinney's videos or books if you want more info -- he recommends drinking a few full-sodium stock cubes every day. Another common issue during adaption seems to be not eating enough fat.

Re: How Ketogenic Diets Curb Inflammation in the Brain

#16

Earlier quoted context omitted.

Definitely not a fad per se. They way it is packaged (Keto) and delivered to the masses makes it seem fad-ish as all quickly ramped-up-to-make-money deals tend to be. I've used keto myself several times though only as short-term diet change. I myself never fully seemed to recover from the Keto-flu even after months of eating strict keto. Adding back natural complex carbs helped me immensely in that regard.

As trevyn says, you need to make sure you get enough sodium. Ketogenic diet accelerates excretion of sodium ("natriuresis of fasting"). Look up Steve Phinney's videos or books if you want more info -- he recommends drinking a few full-sodium stock cubes every day. Another common issue during adaption seems to be not eating enough fat.

Won't adding salt to meals and perhaps a pinch to water in the morning be sufficient?

Re: How Ketogenic Diets Curb Inflammation in the Brain

#17
Work in this area is interesting but to me seems like pharma money as the focus is on messing with things that suck money for a long time and then end in cancer. Or put another way what happens to the carbs that are blocked from getting processed. Knowing which cell types are the most resistant to this intervention may have lots of value, but a new block buster drug would be a crime. So suck it up and learn to truly get into a ketogenic state then see where in the world you are. There is little research on multiyear ketogenic cohorts. Fasting which has many comparators to ketosis has been in most cultures for years. A general theme here is insulin sensitivity or better put lack there of. I do not see how this pathway disrupting mechanism helps to return insulin sensitivity for a person eating the diets recommended by pretty much all governments globally.

Re: How Ketogenic Diets Curb Inflammation in the Brain

#20
post #3
post #2

The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…

Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.

Some people find it easier to sustain a ketogenic diet when eating only from the animal kingdom: https://www.reddit.com/r/zerocarb/
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