How Ketogenic Diets Curb Inflammation in the Brain
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Re: How Ketogenic Diets Curb Inflammation in the Brain
#2The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction:
> In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation,
While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth is it is not strong, not well reproduced and there reasonable logical models that strongly bring the keto claims into question.
That doesn't mean keto is stupid or not worth studying. It's just that the interesting things about keto aren't really the metabolic changes (which are controversial, and small even if existent), but the behavioral controls. Obviously it's an oversimplification to draw a strict line between metabolism and compliance, but the point is the important difference with keto is that for some people it helps them comply to a calorically balanced diet, not that the macronutrient composition is making a difference.
Re: How Ketogenic Diets Curb Inflammation in the Brain
#3The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
Re: How Ketogenic Diets Curb Inflammation in the Brain
#4The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
Depends on how you do it. If you completely limit your diet, that's not sustainable. There are alternative versions, such as the CKD. (Which means you have a regular cheat day)
> People drop off and regain all of their weight.
That's pretty much true with all diets.
Re: How Ketogenic Diets Curb Inflammation in the Brain
#5The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
This doesn't seem to be as big a problem with keto as with other forms of diet adaptation, though. (Although, I'd provide evidence for that, if I had anything but anecdotes to back it up with..)
Re: How Ketogenic Diets Curb Inflammation in the Brain
#6Earlier quoted context omitted.
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
This doesn't seem to be as big a problem with keto as with other forms of diet adaptation, though. (Although, I'd provide evidence for that, if I had anything but anecdotes to back it up with..)
Another anecdote here, for what it’s worth (not much)
Re: How Ketogenic Diets Curb Inflammation in the Brain
#7kinda related: Richard Veech (not in OP article) is probably the doctor/researcher (to my knowledge) has done the best research into ketosis, imo.
https://irp.nih.gov/pi/richard-veech
He's found some very interesting results about the improvement of cellular energy efficiency (thermodynamic improvement)/cellular homeostasis due to keto throughout his career:
- neurons were less thermodynamically wasteful in terms of excess heat generated (because more efficient delta-G/easier ionic potentials); and therefore, due to neuronal metabolic dysfunctions induced by concussions, ketosis was good for treating concussion. DARPA has apparently sunk quite a lot of money into his research of the treatment of concussions/TBI (because of IEDs, etc) - e.g., this paper sponsored by DARPA https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102124/
- cardiac cells too performed more efficiently with ketone bodies
(- if I recall correctly (which I'm not sure that I do..) some breeds of mice were able to hold their breath underwater for something ridiculous like 150% (or more?) of the normal length of time than control group mice could. I can't seem to find the source for this.. [although, anecdotally, there have been 4 or 5 times when (in ketosis) I could hold my breath for >2 minutes (timed) with ease, whereas out of ketosis I'd be barely capable of doing so after, say, 45 seconds..])
Re: How Ketogenic Diets Curb Inflammation in the Brain
#8The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
I've tried tons of diets over the years and keto is by far the only one I've had success with maintaining long term. Even when I take a cheat day, carbs just don't taste that good any more so I end up feeling bloated and go right back on keto.
Re: How Ketogenic Diets Curb Inflammation in the Brain
#9The problem with basically all of the keto science (this study included) is that it doesn't adequately differentiate between the effects of a ketogenic diet and simple caloric restriction: > In rodents, ketogenic diets – and caloric restriction, in general – are known to reduce inflammation, While there is some science showing differences in calorically balanced diets that vary in macronutrient composition, the truth…
Also: people are not rodents
See rats & vitamin c for an example
Re: How Ketogenic Diets Curb Inflammation in the Brain
#10Earlier quoted context omitted.
Another problem is keto seems difficult to sustain over the long term. People drop off and regain all of their weight.
Depends on how you do it. If you completely limit your diet, that's not sustainable. There are alternative versions, such as the CKD. (Which means you have a regular cheat day) > People drop off and regain all of their weight. That's pretty much true with all diets.
Exactly.
Oh hey, I have incurable brain inflammation Let’s not do Keto because it’s unsustainable, I’ll just have oh so sustainable brain inflammation instead