Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
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Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#2From the abstract:
[...] Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. [...]
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#3From the abstract: [...] Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. [...]
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Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#4Before self-medicating based on this combined with a self-diagnosis, consider that LSD and psilocybin have a nasty tendency of triggering latent psychological conditions if not taken in the appropriate dosage and in a controlled environment.
[ref: http://www.nationaldrugstrategy.gov.au/internet/drugstrategy... ]
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#5Before self-medicating based on this combined with a self-diagnosis, consider that LSD and psilocybin have a nasty tendency of triggering latent psychological conditions if not taken in the appropriate dosage and in a controlled environment. [ref: http://www.nationaldrugstrategy.gov.au/internet/drugstrategy... ]
Definitely. Probably is a good resource for psychiatrist as a treatment strategy rather than a protocol for patients to self direct.
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#6From the abstract: [...] Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. [...]
yeah, very interesting
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#7Before self-medicating based on this combined with a self-diagnosis, consider that LSD and psilocybin have a nasty tendency of triggering latent psychological conditions if not taken in the appropriate dosage and in a controlled environment. [ref: http://www.nationaldrugstrategy.gov.au/internet/drugstrategy... ]
Definitely. Probably is a good resource for psychiatrist as a treatment strategy rather than a protocol for patients to self direct.
I can swear I came across a study I found, I believe, on Erowid, which noted this link had a lower instance of increased mental illness than religious "meccas" do.
In light of that evidence, it's entirely possible the human experience itself, and not some more mechanistic action or first order effect of the drug, cause the increase in mental illness.
I'm trying to find this source, but am coming up short and on mobile, but will look into it later.
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#8Before self-medicating based on this combined with a self-diagnosis, consider that LSD and psilocybin have a nasty tendency of triggering latent psychological conditions if not taken in the appropriate dosage and in a controlled environment. [ref: http://www.nationaldrugstrategy.gov.au/internet/drugstrategy... ]
Actually, I think this is more a risk of marijuana, which in the US, is prescribable in several states, legal in a few, and decriminalized in most.
Which is not to say that I encourage recklessness with psychedelics, but that forasmuch as that is a concern with LSD or psilocybin, we're got bigger fish on our hands. Marijuana is much more available than either of those.
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#9Before self-medicating based on this combined with a self-diagnosis, consider that LSD and psilocybin have a nasty tendency of triggering latent psychological conditions if not taken in the appropriate dosage and in a controlled environment. [ref: http://www.nationaldrugstrategy.gov.au/internet/drugstrategy... ]
I'd definitely advise anyone thinking about this to do their research but the risk doesn't seem to be as large as often suggested. There was a large US study that showed no correlation between lifetime psychedelic use and mental health problems.
"[...] lifetime use of LSD, psilocybin, mescaline, or peyote, or past year use of LSD, was not associated with a higher rate of mental health problems."
https://www.nature.com/news/no-link-found-between-psychedeli... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747247/
Re: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
#10Assuming that psilocybin is effective at treating depression, I find myself wondering whether actual conscious experience (that is, being high) is an essential part of its effectiveness or not.
To put this another way, imagine someone takes whatever dose of psilocybin and then is rendered unconsciousness until the perceptual effects wear off. Will there be any difference in its effectiveness as a treatment for depression?