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Could ayahuasca have health benefits?

bbc.co.uk

11–20 of 161 posts

Re: Could ayahuasca have health benefits?

#11
post #5

I don't have any evidence of this but I stronly suspect that doing regular meditation will reduce the chance of bad trips or atleast let you deal with them much better. I'm saying this in case someone decides to experiment with DMT or other halucinogens, you should seriously consider trying meditation as a prerequisite.

Just general health is a good prerequisite. I always liked to have a center/grounding focus for a trip if it starts to go off kilter. Back in High school I would use my world of warcraft character alot. That definitely seems dumb and not at all spiritual on reflection, but it would help ground me and lighten the mood (also he was a badass warrior so it was just cool to think about).

Re: Could ayahuasca have health benefits?

#12
It's modulating the expression of some important genes;

"It is also a selective inhibitor of the human cytochrome P450 isozyme 2D6 (CYP 2D6)"

https://www.ncbi.nlm.nih.gov/pubmed/16149329

"the inhibitions on human liver CYP3A4 and CYP2D6 enzymes by those β-carboline alkaloids were studied kinetically. Harmine, harmol and harmane exhibited noncompetitive inhibition on the activity of CYP3A4 with K(i) values of 16.76, 5.13 and 1.66 μM, respectively. These β-carboline alkaloids were also found to be both substrates and inhibitors for CYP2D6. Harmaline, harmine and harmol showed typical competitive inhibition on the activity of CYP2D6

Inhibition of Human Cytochrome P450 Enzymes 3A4 and 2D6 by β-Carboline Alkaloids, Harmine Derivatives (PDF Download Available). Available from: https://www.researchgate.net/publication/50834428_Inhibition... [accessed Oct 1, 2017]."

https://www.researchgate.net/publication/50834428_Inhibition...

Re: Could ayahuasca have health benefits?

#13
> Could psychedelic drug ayahuasca have health benefits?

Certainly, anecdotally I kicked a very strong 20 year coffee and sugar habit after doing a 3-day retreat in Latin America this past winter. Just happened naturally, oh, I don't need this daily coffee and sugar fix anymore.

On the flip side, as the article mentions, the psychedlic tourism industry as a whole doesn't have formal safe guards in place for when the shit hits the fan with one (or more) of the attendees. My friend, who sat all eleven days, said that two women just completely lost it on day 3, screaming hysterically, out of their minds battling unknown demons.

The retreat "helpers", do the best they can to settle you down, but when you're deep in the experience it's very hard to distinguish between real/unreal. For example, in some kind of existential moment I shouted out in my mind's eye, "you are the most high!". In reality I shocked the 30 other attendants out of their seats, and a helper rushed up to see if I was Ok.

It's an extremely powerful substance. At the end of the retreat, when everyone headed off to sleep, I was still tripping so hard that sleep was impossible. When I finally lay down the sheer flow of non-stop Dali/Escher-like hallucinations running through my mind were sufficient to make me question whether I was ever going to return to reality -- Pandora's box indeed.

tl;dr; proceed with caution, can have beneficial side-effects.

Re: Could ayahuasca have health benefits?

#14
WOW. I really enjoy whenever psychedelics hit the mainstream.

I'm sitting on the fence regarding psychedelic coming out: blog.mostlydoing.com/2016/04/7-reasons-why-you-dont-psychedelic.html

Those who know know, default legal system is still unadvantageous towards drug users.

Re: Could ayahuasca have health benefits?

#15
post #5

I don't have any evidence of this but I stronly suspect that doing regular meditation will reduce the chance of bad trips or atleast let you deal with them much better. I'm saying this in case someone decides to experiment with DMT or other halucinogens, you should seriously consider trying meditation as a prerequisite.

Anything specific practices you recommend? I'm not interested in ayahuasca, but meditation has been on my list for a while now.

'The Mind Illuminated' by Culadasa aka John Yates is an excellent guide.

It takes you gently through 10 stages, from just beginning all the way up to Enlightenment (for some definition of Enlightenment). It thoroughly covers all bases without any mumbo jumbo.

It does however require you to ramp up your practice to at least an hour daily if you want to make the most of it. Personally I found this a little daunting at first, but now that I 'get it' I am actually really motivated to put in the time and I am getting a lot out of it.

Re: Could ayahuasca have health benefits?

#16
post #5

I don't have any evidence of this but I stronly suspect that doing regular meditation will reduce the chance of bad trips or atleast let you deal with them much better. I'm saying this in case someone decides to experiment with DMT or other halucinogens, you should seriously consider trying meditation as a prerequisite.

Anything specific practices you recommend? I'm not interested in ayahuasca, but meditation has been on my list for a while now.

The Mindful Geek (http://a.co/egwKvoo) could be a good starting point for the HN crowd. I'm about halfway through it and I enjoy the no-frills explanations of various meditation techniques.

In my experience, the most difficult part is keeping the practice in my daily routine. Just like with exercise, it's easier to absorb it into your lifestyle if you have a coach or a group of people with which you regularly train.

Re: Could ayahuasca have health benefits?

#17
post #8

Earlier quoted context omitted.

Anything specific practices you recommend? I'm not interested in ayahuasca, but meditation has been on my list for a while now.

Install an app and start - Headspace is popular and easy to get going with. There are lots of different practices, sure, but it's a lot like jogging: you don't need to learn a lot of technique, just need to get up and do it.

I can’t tell if you’re joking with the app or not.

If you’re good enough to meditate around the app, you don’t need any help from the app to start!

Re: Could ayahuasca have health benefits?

#19
post #9

Ayahuasca is a South American brew consisting of two plants one consisting of a MAOI and another of DMT (the exact plant genus differs). DMT without a MAOI gets broken down by the blood brain barrier, so its not efficient without the MAOI. The MAOI however puts dietary restrictions before the drug is being administered, and also makes the drug last vastly longer. Without the MAOI, the DMT wouldn't last long (IIRC eve…

My only DMT experience lasted about 15 minutes, and that was plenty.

Re: Could ayahuasca have health benefits?

#20

It might be easier to find out, if rigorous research into psychedelics weren't so arbitrarily difficult compared to other medicines.

Nothing will happen until psychedelics are rescheduled. It's a travesty that even the "natural" tryptamines (psilocybin/psilocin and DMT) can't be researched more easily.
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