It is a bit fun how some think they can track if I open emails from them or not. I have several times got email with something like "we see you are not reading the emails you get from us, so we will remove you from our list". I did read the emails using Thunderbird, so was only their tracking that didn't work. But this is maybe what we get when most read emails in web apps from companies that want to track everything…
2) Marketers should not rely on opens alone to determine who is inactive. Also look at clicks, and site activity from the past 6 months.