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New antibody attacks 99% of HIV strains

bbc.com

251–256 of 256 posts

Re: New antibody attacks 99% of HIV strains

#251

Earlier quoted context omitted.

It's not the most virulent 1%, it's 1% which have unusual mutations that cause them to be resistant to this treatment, but which usually reduce their fitness in other respects. (This can be seen in humans as well, e.g. malaria resistance->sickle-cell). The fastest-multiplying viruses are also (obviously) going to be the most common, in the absence of treatment.

This is really fascinating how being really good at something often correlates with being less good at other things (in this case antibiotic resistance seems to be inversely proportional to the potency of the bacteria). This is true not just for bacteria but also for other living creatures; for example animals that have lots of children have very short average lifespans. It makes me think that every living species mu…

My physics brain is now imagining some conserved quantity like the fitness density of a bacteria population. Lol

Re: New antibody attacks 99% of HIV strains

#252
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Re: New antibody attacks 99% of HIV strains

#253

Earlier quoted context omitted.

The concept doesn't exist in the States, sadly. Americans please correct me, but here it's more symptomatic with sexual health: You have a rash/etc, so you go see the doctor. There's no early-detection system where you are reminded to get into a clinic every 2-3 months and get a full test (blood test, swabs, etc) for all the usual suspects: HIV, herpes, chlamydia, etc.

I live in Baltimore, and I'm on PrEP. Everyone I know who takes it, including myself, is required to get tested for STDs every 3 months.

I think that being on PrEP is the exception.

Re: New antibody attacks 99% of HIV strains

#254
post #248

Earlier quoted context omitted.

This is constantly done... Find some new discoveries in basic science. Get finding. Develop a drug. Test and redevelop. Market. Profit.

Based on lowering the costs of R&D? I've yet to see it.

Yes, many people bring their work out of academia and have much lower cost of R&D because they don't have to pay for any of the pre-work.

Reagents are getting cheaper and better as well.

Yesteryears low hanging fruit costs the same as today's low hanging fruit. They are harder to solve though.

And no, I'm not saying everyone single biotech startup is like this or every single researcher does this. And yes many fail, but that's the cost of doing business and it's something that makes things progress.

Re: New antibody attacks 99% of HIV strains

#255
post #229
post #192

Earlier quoted context omitted.

As a Canadian in the US to me this feels like a different kind of horror show. I play bridge and as a result I've been exposed to quite a lot of the elderly dying as a result of chronic conditions given the demographics of the game/sport. In Canada, it seemed we had a charity fundraiser 2-3 times a year for someone affected by some condition the government didn't want to cover due to cost. In the US, I deal with a le…

There's certainly a discussion to be had on what level of care should be provided, how to pay for it, and what to do when the care required isn't provided. I don't hear a lot of complaints about medicare not covering important things (but I only have limited exposure to that), and I assume a US single payer system would essentially be Medicare for all. I do hear complaints about Medicare not paying providers enough,…

Remember how proponents of single payer like to point out that US government healthcare spending per capita is higher than many countries with single payer, even though it only covers part of the population? That's probably related.

Re: New antibody attacks 99% of HIV strains

#256
post #119

Earlier quoted context omitted.

Two questions arise: How many people taking retrovirals have undetectable levels of HIV? Are those people using condoms?

Not a professional, but my wife has HIV (and I don't), so I have a personal interest in the subject. > How many people taking retrovirals have undetectable levels of HIV? According to my wife's doctor, most of them. And if that changes, they attempt to adjust treatment to return to that state. BTW, undetectable appears to mean 20 copies of viral DNA per ml of blood. > Are those people using condoms? Well, we were, fo…

There was a study a few days ago that found out that below threshold viral load means that the patient isn't infectious anymore.

https://www.intomore.com/impact/cdc-acknowledges-that-undete...

Don't take my word for it though, would check with doctors.

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