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New antibody attacks 99% of HIV strains

bbc.com

11–20 of 256 posts

Re: New antibody attacks 99% of HIV strains

#11
post #7
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

I think the 1960's unprotected sex wave was more a symptom of ignorance of STDs. People used to see condoms as primarily for birth control, and not really a sanitary measure. Remember, the birth control pill came out in the 1960s! Even then, knowledge of condoms wasn't widespread like it is now. My grandmother was super-pissed-off when my grandfather told her about them after she was pregnant for 18 months straight!…

Ignorance of STDs was okay in 1960s, because antibiotics worked really great back then and just about every STD was easily curable.

Re: New antibody attacks 99% of HIV strains

#13
post #6

Earlier quoted context omitted.

I disagree. I (annedoctally) heard several times stories about how today's youth (~20yo) doing more unprotected sex than my generation (~35yo) only because HIV "does not kill anymore" . If AIDS is actually curable, I would bet that all other STD would explode in the short term

My friends weren't wrapping it when I was in uni 6-10 years ago because every girl was on birth control.

I am gay so I have used condoms my whole life but my straight friends routinely go out and have unprotected sex all the time, I'd say about 5% of my straight friends consistently use condoms.

Re: New antibody attacks 99% of HIV strains

#15
post #6
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

I disagree. I (annedoctally) heard several times stories about how today's youth (~20yo) doing more unprotected sex than my generation (~35yo) only because HIV "does not kill anymore" . If AIDS is actually curable, I would bet that all other STD would explode in the short term

Isn't there a lot of talk about how today's youth is much less likely to date/engage in sexual activity?

So what you're saying is, they don't always have sex, but when they do it's unprotected? That sounds pretty normal to me.

Re: New antibody attacks 99% of HIV strains

#16
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

99% of strains isn’t necessarily 99% of all infections, and won’t be anything close to it soon after this gets used in humans.

If one assumes that the different strains also compete against each other the total number of infections may not go down much, and if it does, that may only be temporarily.

Re: New antibody attacks 99% of HIV strains

#17

HIV must be the most almost cured disease ever.

In the 1980s, getting HIV was a quick death sentence.

In the 2010s, getting HIV means that you are likely to live until... Your 70s. (Assuming you have access to medication.)

The problem is that you need to take expensive medication for the rest of your life. And that you can infect other people.

Re: New antibody attacks 99% of HIV strains

#18
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

Not really, no. Modern antiretrovirals are exceptionally effective, and for those with access[1] HIV/AIDS has become a chronic illness, with nearly-similar lifespans (due mostly to chronic inflammation).

We still haven't come close to "eradicating" or curing HIV/AIDS; the issue lies in the virus' insidious biology. HIV is a retrovirus, meaning it incorporates into the target cell's genome, specifically CD4+ T-cells. An obvious barrier to "only" 1% of virions is that an infected person produces billions of virus particles every single day[2]. A less obvious barrier is the "latent" reservoir of the virus in cells.

Essentially, not all cells with an incorporated HIV genome are producing virus, and thus these proviruses can evade detection. A 2013 paper in cell[3] provides what I think is the most devastating example of this. Basically, an idea that has gained more traction lately has been to activate these T-cells, thus alerting the immune system and hopefully clearing the virus. It turns out that not all cells are activated, and the size of this reservoir is ~60X larger than previously thought.

When it comes to something like cancer, we often define "cure" or "beating it" differently — look no further than Randall Munroe's heartbreaking visualization, Lanes.[4] We need to do something similar for HIV. We can't get rid of the virus, but we're already pretty good at making life not so bad if you have it. Access and affordability are larger barriers to preventing mortality/morbidity.

There's also a quiet undercurrent that a standard vaccine for HIV is biologically impossible, but that's for another day.

tl;dr HIV sucks but we're okay at managing it. 99% sounds good but it's probably not enough.

1: Read: moderately well-off people with health insurance in wealthy, industrialized nations.

2: DOI: 10.1038/nrg1246 The oft-cited rule of the thumb is that every base of the viral genome is mutated every day.

3: DOI: 10.1016/j.cell.2013.09.020 This one is absolutely worth reading.

4: https://xkcd.com/931

Re: New antibody attacks 99% of HIV strains

#19
post #6
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

I disagree. I (annedoctally) heard several times stories about how today's youth (~20yo) doing more unprotected sex than my generation (~35yo) only because HIV "does not kill anymore" . If AIDS is actually curable, I would bet that all other STD would explode in the short term

That's factually untrue according to the National Survey of Sexual Health and Behavior[0]. The facts are[1] that the younger the age group the higher the condom usage is.

And while condom use has fallen a little since its height, it still remains significantly higher amongst the young than any older generation or group.

[0] http://www.nationalsexstudy.indiana.edu/ [1] http://www.nationalsexstudy.indiana.edu/condomgraph.html

Re: New antibody attacks 99% of HIV strains

#20
post #4

Well, 99% means eradication of the virus very quickly. People won't become totally sexually irresponsible after the preventive shot, because there are many other hard to cure STDs now, especially as antibiotics are not as potent as they use to be, so i think there is no threat of 1960s style of unprotected sex wave.

"sexual responsibility" is quite an odd concept, it should be defined more precisely.
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