As someone who is finally getting into Python development (via Django) after following tons of tutorials over several years: should I be using pew, virtualenvwrapper, or something else? This article is from 2015, how relevant is it today?
More recent tools are Pipenv (which I've been using) and hatch - I don't think there is any One True Way since the days of virtualenvwrapper being the latest and shiniest.
If you want a really easy to use tool that doesn't require any understanding of virtualenvs, I'd look at Pipenv.